Herbicidal acetals and ketals

ABSTRACT

Novel furan- and thiophenesulfonamides such as 3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3-5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide and N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1, 3-dioxolan-2-yl)-2-thiophenesulfonamide are highly active pre-emergent and/or post-emergent herbicides.

This is a division of application U.S. Ser. No. 006,434 filed Jan. 23, 1987, now U.S. Pat. No. 4,753,672 which in turn is a division of application U.S. Ser. No. 754,709 filed July 16, 1985, now U.S. Pat. No. 4,659,369, which in turn is a continuation-in-part of application U.S. Ser. No. 644,259 filed Aug. 27, 1984, now abandoned.

BACKGROUND OF THE INVENTION

The present invention relates to a novel class of furan- and thiophenesulfonamide compounds and their use as pre-emergent and post-emergent herbicides and as plant growth regulants.

U.S. Pat. Nos. 4,169,719 and 4,127,405 disclose herbicidal benzene-, furan- and thiophenesulfonamides of general formula ##STR1## where R₁ may be an optionally substituted benzene or a furan or thiophene substituted with H, Cl, Br or CH₃.

U.S. Pat. No. 4,398,939 discloses herbicidal thiophenesulfonamides of formula ##STR2## where R is C₁ -C₄ alkyl, C₃ alkenyl, OCH₃, NO₂, Cl, Br, SO₂ NR₁ R₂ or SO₂ N(OCH₃)CH₃.

European patent application (EP-A) No. 30,142, published 6/10/81 discloses herbicidal furan- and thiophenesulfonamides of formula ##STR3## where W' is O or S;

A is C(O)QR^(I) or C(═T)R^(II) ; and

A' is H, Cl, Br, C₁ -C₄ alkyl, OCH₃, NO₂ or CF₃.

U.S. Pat. No. 4,370,480 teaches herbicidal benzenesulfonamides of general formula ##STR4## where R₁ is ##STR5##

EP-A-64,804, published 11/17/82, teaches herbicidal furan- and thiophenesulfonamides of general formula ##STR6## where R₁ is S(O)_(n) R₆ ; and

R₂ is H, Cl, Br or CH₃ ;

EP-A-13,480 discloses herbicidal pyridine-sulfonamides of formula ##STR7## where R₁ is H, Cl, Br, F, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkylthio, NO₂ or CO₂ R₅ ; and

R₂ is H, Cl, Br or CH₃.

EP-A-35,893 discloses herbicidal pyridine-sulfonamides of formula ##STR8## where R₁ is S(O)_(n) R₃ ; and

R₂ is H, Cl, F, Br, CH₃, OCH₃, CF₃, NO₂, CN or NH₂.

EP-A-97,122, published Dec. 28, 1983, discloses herbicidal sulfonamides of formula ##STR9## where X is O, S, NR₄ or CR₅ ═N; and

R₂ is H, C₁ -C₃ alkyl, haloalkyl, alkoxy, alkylthio, alkylsulfonyl, halogen, NO₂, CWR₈, SO₂ NR₆ R₇ or COR₉.

EP-A-95,925, published Dec. 7, 1983, and EP-A-87,780, published Sept. 7, 1983, teach herbicidal pyrazole sulfonylureas.

EP-A-95,925 (published Dec. 7, 1983) and EP-A-87,780 (published Sept. 7, 1983) teach herbicidal pyrazole sulfonylureas.

EP-A-126,711 (published 11/28/84; Swiss priority 5/16/83) discloses herbicidal sulfonylureas of the formula ##STR10## wherein X is O, S, --NR₅, ##STR11## --CH═CH-- or an annelated phenyl ring; Z is O or S;

Q is halogen, C₁ -C₄ alkyl, cyano, etc.;

R₁ is H, halogen, NO₂ or a group ##STR12## R₆ is, inter alia, H or C₁ -C₄ alkyl; and R₂ and R₃ can be, among other things, C₁ -C₄ alkyl or C₁ -C₄ alkoxy.

SUMMARY OF THE INVENTION

This invention relates to novel compounds of Formula I, agriculturally suitable compositions containing them and their method-of-use as preemergent and/or postemergent herbicides or plant growth regulants. ##STR13## wherein Q is ##STR14## R is H or CH₃ ; R₁ is ##STR15## E is CH₂ or a single bond; R₂ is H, C₁ -C₂ alkyl or Cl;

R₃ is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy;

R₄ and R₅ are independently C₁ -C₂ alkyl;

R₆ and R₇ are independently H or C₁ -C₂ alkyl;

W is O or S;

W₁ is O or S;

Q₁ and Q₂ are independently O, S or NCH₃ ; A is ##STR16## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃)alkylamino;

Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylsulfinylalkyl, C₁ -C₄ haloalkyl, C₂ -C₅ alkylsulfonylalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl, C₂ -C₅ alkylthioalkyl, C(O)R₈, ##STR17## or N(OCH₃)CH₃ ; m is 2 or 3;

L₁ and L₂ are independently O or S;

R₈ is H or CH₃ ;

R₉ and R₁₀ are independently C₁ -C₂ alkyl;

R₁₁ is C₁ -C₃ alkyl;

R₁₂ is H, F, Cl, NO₂, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂ alkylsulfinyl, C₁ -C₂ alkylsulfonyl, di(C₁ -C₂)alkylsulfamoyl or CO₂ (C₁ -C₂ alkyl);

R₁₃ is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F or NO₂ ;

R₁₄ is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkyl, C₁ -C₃ haloalkoxy, Cl, Br, F, NO₂, di(C₁ -C₃)alkylsulfamoyl, C₁ -C₃ alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, CH₂ OCH₃, CH₂ SCH₃ or CH₂ CN.

Z is CH or N;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H; and

Y₂ is H or CH₃ ;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₃ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, OCF₂ H, SCF₂ H, CH₃ or C₂ H₅ ;

X₃ is CH₃ or OCH₃ ;

Y₄ is CH₃, OCH₃, OC₂ H₅ or Cl; and

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;

and their agriculturally suitable salts; provided that

(a) when X is Cl, F, Br or I, then Z is CH and Y is OCH₃, OC₂ H₅, N(OCH₃)CH₃, NHCH₃, N(CH₃)₂ or OCF₂ H;

(b) when Y is cyclopropyl, X is other than Cl, F, Br or I;

(c) when R₃ is C₁ -C₃ alkoxy, then Q₁ and Q₂ are oxygen;

(d) when R₃ is H or C₁ -C₃ alkyl, then Q is Q-1 through Q-9;

(e) when X or Y is OCF₂ H, then Z is CH;

(f) when the total number of carbon atoms of X and Y is greater than four, then the combined number of carbons of the substituents on Q is less than or equal to ten;

(g) when W is S, then A is A-1, R is H, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR18## (h) when A is A-7 and Z is N, then R₃ is C₁ -C₃ alkoxy; (i) when E is CH₂, then R₁₄ is H, CH₃, OCH₃, Cl or NO₂ and is not in the 4-position.

In the above definitions, the term "alkyl" used either alone or in compound words such as "alkylthio" or "haloalkyl", denotes straight chain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or the different butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the different butoxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g., 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g., ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers.

Cycloalkyl denotes cyclopropyl, cyclobutyl and cyclopentyl.

The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine or iodine.

In terms such as C₂ -C₅ alkoxyalkoxy, the specified number of carbon atoms is meant to define the total number of carbon atoms in that substituent group. For example, C₂ -C₅ alkoxyalkoxy would represent OCH₂ OCH₃ through O(CH₂)₄ OCH₃ or OCH₂ O(CH₂)₃ CH₃ and the various structural isomers embraced therein.

Alkylsulfonyl denotes methylsulfonyl, ethylsulfonyl and the different propylsulfonyl isomers.

Alkylthio, alkylsulfinyl, alkylamino, alkylsulfamoyl, etc., are defined in an analogous manner.

PREFERRED COMPOUNDS

Preferred for reasons of their higher herbicidal efficacy, greater plant growth regulant activity and/or more favorable ease of synthesis are:

(1) Compounds of Formula I where

R₃ is H or C₁ -C₃ alkyl;

(2) Compounds of Formula I where

R₃ is C₁ -C₃ alkoxy;

(3) Compounds of Preferred 1 where

W is O;

R is H;

X is CH₃, OCH₃, OC₂ H₅, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ; and

Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, CH₂ OC₂ H₅, ##STR19## OCF₂ H, C.tbd.CH, C.tbd.CCH₃, SCF₂ H or cyclopropyl;

(4) Compounds of Preferred 3 where

Q₁ and Q₂ are identical and are O or S;

R₁₂ is H, C₁ -C₂ alkyl or Cl;

R₁₃ is H; and

(5) Compounds of Preferred 4 where

A is A-1;

Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, NHCH₃, CH₂ OC₂ H₅, OCF₂ H, OCH₂ CH₂ OCH₃, cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ; and

X is CH₃, OCH₃, Cl, OC₂ H₅, OCF₂ H or OCH₂ CF₃ ;

(6) Compounds of Preferred 5 where Q₁ and Q₂ are O;

(7) Compounds of Preferred 5 where Q₁ and Q₂ are S;

(8) Compounds of Preferred 5 where Q is Q-1;

(9) Compounds of Preferred 5 where Q is Q-2;

(10) Compounds of Preferred 5 where Q is Q-3;

(11) Compounds of Preferred 5 where Q is Q-4;

(12) Compounds of Preferred 5 where Q is Q-5;

(13) Compounds of Preferred 5 where Q is Q-6;

(14) Compounds of Preferred 5 where Q is Q-7;

(15) Compounds of Preferred 5 where Q is Q-8;

(16) Compounds of Preferred 5 where Q is Q-9;

(17) Compounds of Preferred 2 where

W is O;

R is H;

X is CH₃, OCH₃, OC₂ H₅, Cl, F, Br, I, OCF₂ H, CH₂ F, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ; and

Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, CH₂ OC₂ H₅, ##STR20## OCF₂ H, SCF₂ H, cyclopropyl, C.tbd.CH or C.tbd.CCH₃ ;

(18) Compounds of Preferred 17 where

E is a single bond;

R₁₂ is H, C₁ -C₂ alkyl or Cl;

R₁₃ is H; and

R₁₄ is H, F, Cl, Br, C₁ -C₂ alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkylthio and is not para to the sulfonylurea bridge;

(19) Compounds of Preferred 18 where

A is A-1;

Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, NHCH₃, CH₂ OC₂ H₅, OCF₂ H, OCH₂ CH₂ OCH₃, cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ; and

X is CH₃, OCH₃, Cl, OC₂ H₅, OCF₂ H or OCH₂ CF₃ ;

(20) Compounds of Preferred 19 where Q is Q-1;

(21) Compounds of Preferred 19 where Q is Q-2;

(22) Compounds of Preferred 19 where Q is Q-3;

(23) Compounds of Preferred 19 where Q is Q-4;

(24) Compounds of Preferred 19 where Q is Q-5;

(25) Compounds of Preferred 19 where Q is Q-6;

(26) Compounds of Preferred 19 where Q is Q-7;

(27) Compounds of Preferred 19 where Q is Q-8;

(28) Compounds of Preferred 19 where Q is Q-9;

(29) Compounds of Preferred 19 where Q is Q-10;

Specifically Preferred for reasons of highest herbicidal efficacy and/or most favorable ease of synthesis are:

3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide, m.p. 164°-166° C.; and

N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide, m.p. 137°-150° C.

DETAILED DESCRIPTION OF THE INVENTION Synthesis

The compounds of Formula I can be prepared by one or more of the methods shown in Equations 1-7.

As shown in Equation 1, compounds of Formula I (where W is O) can be prepared by treating sulfonamides of Formula II with phenyl esters of N-heterocycliccarbamic acids of Formula III in the presence of a strong organic base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). ##STR21## wherein Q, R and A are as previously defined. The reaction of Equation 1 is generally carried out in the range of 0° to 50° C. in an inert solvent such as dioxane or acetonitrile, analogous to methods taught in EP-A 44,807. The required carbamates can be prepared from the corresponding amines, IIIa, and diphenyl carbonate or phenylchloroformate and a base such as sodium hydride as shown in Equation 2. ##STR22##

Compounds of Formula I may also be prepared as shown in Equation 3 by treating sulfonamides of Formula II with the methyl ester of an N-heterocycliccarbamic acid of Formula IIIb in the presence of an equimolar quantity of trimethylaluminum. ##STR23##

The reaction of Equation 3 is best carried out at temperatures between 25° and 83° C. in a solvent such as methylene chloride or 1,2-dichloroethane for 12 to 95 hours under an inert atmosphere, as taught in EP-A 84,244, published July 27, 1983. The methyl carbamates, IIIb, can be conveniently synthesized by treatment of the corresponding heterocyclic amines of Formula IIIa with dimethyl carbonate or methyl chloroformate in the presence of a base such as sodium hydride.

Alternatively, compounds of Formula I can be prepared by the reaction of a sulfonylcarbamate of Formula IV with an aminoheterocycle of Formula IIIa as shown in Equation 4. ##STR24##

The reaction is carried out at 50° to 100° C. in a solvent such as dioxane for 0.5 to 24 hours as taught in EP-A-44,807. The required carbamates of Formula IV are prepared by the reaction of the corresponding sulfonamides of Formula II with diphenylcarbonate or phenylchloroformate in the presence of a base such as sodium hydride.

Compounds of Formula I, where W is S, can be prepared via addition of an appropriate heterocyclic amine, IIIa, to a sulfonyl isothiocyanate of the formula QSO₂ NCS. This reaction is best carried out according to methods taught in U.S. Pat. No. 4,127,405.

Sulfonyl isothiocyanates of the formula QSO₂ NCS can be prepared according to the procedure of K. Hartke, Arch. Pharm., 299, 174 (1966).

Sulfonamides of Formula II used in the preparation of compounds of Formula I are useful intermediates. They can be prepared by a variety of methods known in the art. For example, contacting an appropriately substituted sulfonyl chloride IIa with ammonium hydroxide or ammonia in an inert solvent such as ether or tetrahydrofuran affords sulfonamides II as shown by Equation 5a and 5b. ##STR25##

The reaction of sulfonyl chlorides, IIa, with ammonia is best carried out at -33° to 50° C. for 0.1 to 24 hours. After removal of the ammonium chloride by-product by filtration or extraction with water, the desired product can be isolated by the evaporation of the organic solvent.

Ammonium hydroxide can be used in place of ammonia as in Equation 5b. This reaction is widely reported in the literature, c.f., Methoden Der Organischen Chemie (Houben-Weyl), Vol. 9, Ch. 19, edited by F. Muth, Stuttgart, 1955.

Alternatively, sulfonamides of Formula II can be prepared by the reaction of a lithium salt of an appropriately substituted sulfinic acid, IIb, with chloramine as shown in Equation 6. ##STR26##

This reaction can be carried out using the conditions referred to in the preceding reference.

Lithium salts of Formula IIb can also be converted to the sulfonamides of Formula IIa by the procedures taught in U.S. Pat. No. 4,441,910.

Sulfonyl chlorides of Formula IIa can be prepared by the reaction of lithium salts of Formula IIc with sulfuryl chloride at -50° to -20° C. in an inert solvent such as tetrahydrofuran or ether as shown in Equation 7.

    ______________________________________                                         Equation 7                                                                     ______________________________________                                         (a) QH + R'Li  →      QLi                                                                            IIc                                               (b) QBr + R'Li →      IIc                                               (c) IIc + SO.sub.2 Cl.sub.2                                                                   →      IIa                                               ______________________________________                                    

Where R' is a group such as butyl, phenyl, diisopropylamino or similar moiety commonly combined with lithium to form a lithiation agent. These agents and their method of use are described in N. S. Narasimhan and R. S. Mali, Synthesis, 957-86 (1983) or in The Chemistry of Organolithium Compounds, Wakefield, Pergamon Press, Oxford, 1974 or also H. W. Gschwend and H. R. Rodriguez, Org. React. 26, 1 (1978).

The sulfonyl chlorides, IIa, can be isolated by extracting the inorganic by-products with water followed by drying the organic layer over a drying agent such as magnesium sulfate, filtering the dried solution and evaporation of the solvent.

Lithium salts of Formula IIb can be prepared by contacting sulfur dioxide with the lithiated intermediate IIc using procedures described in the above references on the lithiated intermediates.

The formation of orthoesters, acetals, cyclic acetals, thioacetals and their amino analogs where Q₁ or Q₂ are N--CH₃ is widely reported in the literature, c.f.: Synthetic Organic Chemistry, R. B. Wagner and H. D. Zook, Ch. 8, John Wiley & Sons, New York, 1953; or Organic Synthesis, V. Migrdichian, Ch. 5, Reinhold, London, 1957.

The desired aldehyde and acetyl substituted thiophenes can be prepared by a variety of methods as described, for example, in "The Chemistry of Heterocyclic Compounds", vol. 3, edited by H. D. Hartough, F. P. Hochgesang and F. F. Blicke, Interscience, N.Y., 1952. Pyrazole aldehydes and acetylpyrazoles can be prepared according procedures described in "The Chemistry of Heterocyclic Compounds", Vol. 22, edited by R. H. Wiley, Interscience, N.Y., 1967. Aldehydes and acetyl derivatives of furan can be prepared according to methods cited in "Advances in Heterocyclic Chemistry", Vol. 7, edited by A. R. Katritzky and A. J. Boulton, and Vol. 30 edited by A. R. Katritzky, Academic Press, N.Y., 1962 and 1982. Further references to the literature of heterocyclic compounds can be found on pages 225-299 of Vol. 7 cited above.

The heterocyclic amines of Formula IIIa can be prepared by methods known in the literature, or simple modifications thereof, by those skilled in the art. For instance, EP-A No. 84,224 (published July 27, 1983) and W. Braker et al., J. Am. Chem. Soc., 69, 3072 (1947) describes methods for preparing aminopyrimidines and triazines substituted by acetal groups such as dialkoxymethyl or 1,3-dioxolan-2-yl, among other groups. Also, for example, South African patent application Nos. 82/5045 and 82/5671 describe methods for preparing aminopyrimidines and triazines substituted by haloalkyl or haloalkylthio groups such as OCH₂ CH₂ F, OCH₂ CF₃, SCF₂ H, or OCF₂ H, among other groups. South African patent application 83/7434 (published Oct. 5, 1983) describes methods for the synthesis of cyclopropylpyrimidines and triazines substituted by such groups as alkyl, haloalkyl, alkoxy, haloalkoxy, alkylamino, dialkylamino or alkoxyalkyl.

The 5,6-dihydrofuro[2.3-d]pyrimidin-2-amines, the cylcopenta[dπpyrimidin-2-amines (IIIa, A is A-2) and the 6,7-dihydro-5H-pyrano[2.3-d]pyrimidin-2-amines (IIIa, A is A-3) can be prepared as described in EP-A No. 15,683. The furo[2.3-d]pyrimidin-2-amines (III, A is A-4) are described in EP-A No. 46,677.

Compounds of Formula IIIa, where A is A-5, are described in EP-A-73,562. Compounds of Formula IIIa, where A is A-6, are described in EP-A-94,260. Compounds of Formula IIIa, where A is A-7, can be prepared by methods taught in EP-A-125,864.

In addition, general methods for preparing aminopyrimidines and triazines have been reviewed in the following publications:

"The Chemistry of Heterocyclic Compounds," a series published by Interscience Publ., New York and London;

"Pyrimidines", Vol. 16 of the same series by D. J. Brown;

"s-Triazines and Derivatives," Vol. 13 of the same series by E. M. Smolin and L. Rapaport;

F. C. Schaefer, U.S. Pat. No. 3,154,547 and K. R. Huffman and F. C. Schaefer, J. Org. Chem., 28, 1812 (1963), which describes the synthesis of triazines.

Agriculturally suitable salts of compounds of Formula I are also useful herbicides and can be prepared in a number of ways known in the art. For example, metal salts can be made by contacting compounds of Formula I with a solution of an alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide or carbonate). Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formula I can also be prepared by exchange of one cation for another. Cationic exchange can be effected by direct contact of an aqueous solution of a salt of a compound of Formula I (e.g., alkali or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water and can be separated by filtration.

Exchange may also be effected by passing an aqueous solution of a salt of a compound of Formula I (e.g., an alkali metal or quaternary amine salt) through a column packed with a cation exchange resin containing the cation to be exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water-soluble.

Acid addition salts, useful in this invention, can be obtained by reacting a compound for Formula I with a suitable acid, e.g., p-toluenesulfonic acid, trichloroacetic acid or the like.

The preparation of the compounds of this invention is further illustrated by the following specific examples. Unless otherwise indicated, temperatures are given in degrees centrigrade.

EXAMPLE 1 3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonyl chloride

To 23.4 g of 3-(1,3-dioxolan-2-yl)thiophene (S. Gronowitz, et al., Arkiv. Kemi., 20, 407 (1963)) in 100 ml of anhydrous tetrahydrofuran was added 100 ml of 1.6 molar n-butyllithium in hexane, with ice bath cooling. After stirring at room temperature for 20 minutes the mixture was cooled to -78° and sulfuryl chloride (16.2 g) was then added dropwise. This addition caused the suspended solids to form a tarry mass which broke up when the mixture was allowed to warm to room temperasture. After stirring one and one half hours at room temperature the mixture was cooled to -10° and 10 ml of ethyl acetate was added dropwise. The reaction mixture was then poured into ice water and extracted with ethyl ether. The ether portions were combined, dried over magnesium sulfate, filtered and the ether removed in vacuo-to yield 19.6 g of an oil. Infrared absorption spectra of this product showed peaks at 1330 and 1180 cm⁻¹, consistent for the desired sulfonyl chloride. Mass spectrum analysis: calc. 254, found 253 (Mass-1H) and the presence of a chlorine atom.

EXAMPLE 2 3-(1,3-Dioxolan-2-yl)thiophene-2-sulfonamide

To 5 ml of liquified ammonia gas dissolved in 50 ml of tetrahydrofuran was added dropwise with stirring and cooling 12.7 g of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonyl chloride. After stirring overnight at ambient temperature, the tetrahydrofuran was removed in vacuo, water was added to the residue and the mixture was extracted twice with 75 ml of methylene chloride. After washing the combined methylene chloride extracts with water, drying over magnesium sulfate, filtering off the drying agent and evaporation of the methylene chloride, an oily solid residue was obtained. This was chromatographed through silica gel using 1:1 ethyl acetate-hexanes as eluant (Rf 0.35). Evaporation of the solvent mixture yielded 2.2 g of the desired product, as a waxy solid. Infrared absorption spectra showed peaks at 3360, 3260, 1340 and 1140 cm⁻¹, consistent for a primary sulfonamide. Mass spectrum analysis: calc. 235, found 234 (Mass-1H).

EXAMPLE 3 3-(1,3-Dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide

To 0.47 g of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonamide in 20 ml of acetonitrile was added 0.52 g of phenyl(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate and 0.3 ml of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). After stirring at ambient temperatures for two hours the solution was diluted to 50 ml with water and the pH was adjusted to 3 by the addition of hydrochloride acid. The resultant solution was extracted with methylene chloride and the methylene chloride phase was dried over magnesium sulfate, filtered and evaporated. Trituration of the residue with butyl chloride yielded 0.6 g of the product, m.p. 164°-166°. Infrared absorption spectra showed peaks at 1700, 1600 and 1550 cm⁻¹, consistent for the desired structure. ##STR27##

EXAMPLE 4 N-[4,6-Dimethoxypyrimidin-2-yl)aminocarbonyl]-3-(1,3-dioxolan-2-yl)-2-thiophenesulfonamide

To 0.47 g of 3-(1,3-dioxolan-2-yl)thiophene-2-sulfonamide in 20 ml of acetonitrile was added 0.5 g of phenyl (4,6-dimethoxypyrimidin-2-yl)carbamate and 0.3 ml of DBU. After stirring for two hours at ambient temperature, 25 ml of water was added to the mixture and the solution was acidified to pH 3 with 10% hydrochloric acid. The precipitated product was removed by filtration, washed with water and air dried to yield 0.9 g of the subject compound, m.p. 157-168. Infrared absorption peaks at 1700, 1600, 1570 cm⁻¹ were consistent for the desired structure.

    ______________________________________                                         NMR(CDCl.sub.3): δ                                                                          3.95 (m. CH.sub.2 O);                                                          3.95 (s. CH.sub.3 O);                                                          5.77 (s. pyrimidine);                                                          6.44 (s. dioxolane);                                                           7.25 (d. thiophene);                                                           7.57 (d. thiophene).                                        ______________________________________                                    

By using the procedures described in the foregoing equations and examples or modifications thereof, one skilled in the art can prepare the compounds shown in the following tables. ##STR28##

                                      TABLE I                                      __________________________________________________________________________     GENERAL STRUCTURE I                                                            R.sub.1     R.sub.2                                                                            R  W X      Y        Z  m.p. °C.                        __________________________________________________________________________     1,3-dixolan-2-yl                                                                           H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O Cl     OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCF.sub.2 H                                                                           CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CH.sub.2 F                                                                  CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CHF.sub.2                                                                   CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CF.sub.3                                                                    CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                          H   H  O CF.sub.3                                                                              CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CF.sub.3                                                                              OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              NHCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             N(CH.sub.3).sub.2                                                                       N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             N(CH.sub.3)OCH.sub.3                                                                    N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                      N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              SCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.2 CH═CH.sub.2                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.2 C.tbd.CH                                                                      N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.2 CH.sub.3                                                             N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.2 CH.sub.3                                                             N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                            CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                            N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                      N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                      CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH(OCH.sub.3).sub.2                                                                     CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              i-C.sub.3 H.sub.7                                                                       CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH(OCH.sub.3).sub.2                                                                     N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             1,3-dioxolan-                                                                           CH                                                                    2-yl                                               1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             1,3-dioxolan-2                                                                          N                                                                     2-yl                                               1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             4-methyl-1,3-                                                                           N                                                                     dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             4-methyl-1,3-                                                                           CH                                                                    dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             4-ethyl-1,3-                                                                            CH                                                                    dioxolan-2-yl                                      1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             1,3-dioxan-2-yl                                                                         N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             1,3-dioxan-2-yl                                                                         CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             cyclopropyl                                                                             CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                        1,3-dioxolan-2-yl                                                                          H   H  O Br     OCF.sub.2 H                                                                             CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             cyclopropyl                                                                             N                                         1,3-dioxolan-2-yl                                                                          H   H  O F      CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  O F      OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O Br     OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O Br     CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  O I      OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             cyclopropyl                                                                             CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CH.sub.3                                                                    cyclopropyl                                                                             N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CH.sub.2 F                                                                  cyclopropyl                                                                             N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             cyclopropyl                                                                             N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             CH(SCH.sub.3).sub.2                                                                     N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             CH(SCH.sub.3).sub.2                                                                     CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             1,3-dithiolan-                                                                          CH                                                                    2-yl                                               1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             1,3-dithiolan-                                                                          N                                                                     2-yl                                               1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             1,3-oxathiolan-                                                                         N                                                                     2-yl                                               1,3-dioxolan-2-yl                                                                          H   CH.sub.3                                                                          O OCH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   CH.sub.3                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                          H   CH.sub.3                                                                          O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   CH.sub.3                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   CH.sub.3                                                                          O Cl     OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  S CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  S CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  S OCH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                          H   H  S OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.3                                                                             CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                         H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                               CH                                        1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.3                                                                             CH.sub.3 N                                         1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                              N                                         1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                              N                                         --CH(OCH.sub.3).sub.2                                                                      H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --CH(OCH.sub.3).sub.2                                                                      H   H  O CH.sub.3                                                                              CH.sub.3 N                                         --CH(OCH.sub.3).sub.2                                                                      H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N  147-165                                --CH(OCH.sub.3).sub.2                                                                      H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --CH(OCH.sub.3).sub.2                                                                      H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH 156-158                                --CH(OCH.sub.3).sub.2                                                                      H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N  135-139                                --CH(OCH.sub.3).sub.2                                                                      H   H  O Cl     OCH.sub.3                                                                               CH 151-154                                --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H   H  O CH.sub.3                                                                              CH.sub.3 N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N  120-126                                --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH 141-144                                --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH 148-152                                --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H   H  O Cl     OCH.sub.3                                                                               CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                               H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                               H   H  O CH.sub.3                                                                              CH.sub.3 N                                         --CH(OC.sub.2 H.sub.5).sub.2                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --CH(OC.sub.2 H.sub.5).sub.2                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                               H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --CH(OC.sub.2 H.sub.5).sub.2                                                               H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         --CH(SCH.sub.3).sub.2                                                                      H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --CH(SCH.sub.3).sub.2                                                                      H   H  O CH.sub.3                                                                              CH.sub.3 N                                         --CH(SCH.sub.3).sub.2                                                                      H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --CH(SCH.sub.3).sub.2                                                                      H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --CH(SCH.sub.3).sub.2                                                                      H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              CH.sub.3 N                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H   H  O Cl     OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H   H  O Br     OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                              N                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              CH.sub.3 N                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O Cl     OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O Br     OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  1,3-oxathiolan-2-yl                                                                        H   H  O OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                              N                                         1,3-oxathiolan-2-yl                                                                        H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        1,3-oxathiolan-2-yl                                                                        H   H  O CH.sub.3                                                                              CH.sub.3 N                                         1,3-oxathiolan-2-yl                                                                        H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         1,3-oxathiolan-2-yl                                                                        H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        1,3-oxathiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        1,3-oxathiolan-2-yl                                                                        H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         1,3-oxathiolan-2-yl                                                                        H   H  O Cl     OCH.sub.3                                                                               CH                                        1,3-oxathiolan-2-yl                                                                        H   H  O OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                              N                                         2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              CH.sub.3 N                                         dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dithiolan-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O CH.sub.3                                                                              CH.sub.3 N                                         pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         pyrimidin-2-yl                                                                 4,5-dimethyl-1,3-                                                                          H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H   H  O CH.sub.3                                                                              CH.sub.3 N                                         dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H   H  O CH.sub.3                                                                              OCH.sub. 3                                                                              CH                                        dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H   H  O CH.sub.3                                                                              CH.sub.3 N                                         dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  1,3-dimethyl-2-                                                                            H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H   H  O CH.sub.3                                                                              CH.sub.3 N                                         imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        imidazolinyl                                                                   1,3-dioxolan-2-yl                                                                          5-CH.sub.3                                                                         H  O CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          5-CH.sub.3                                                                         H  O OCH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          5-CH.sub.3                                                                         H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          4-CH.sub.3                                                                         H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          4-CH.sub.3                                                                         H  O OCH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                          4-CH.sub.3                                                                         H  O CH.sub.3                                                                              CH.sub.3 N                                         --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub. 3                                                                      H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O Cl     OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O Br     OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              H        CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             H        CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O OCF.sub.2 H                                                                           OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                      CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                         CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O Cl     OC.sub.2 H.sub.5                                                                        CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                                         --C(OCH.sub.3).sub.3                                                                       H   H  O OCF.sub.2 H                                                                           CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               N                                         --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             cyclo-   N                                                                     propyl                                             --C(OCH.sub.3).sub.3                                                                       H   H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              CH.sub.3 N                                         --C(OC.sub.2 H.sub.5)(OCH.sub.3).sub.2)                                                    H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        2-methoxy-1,3-                                                                             H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O Cl     OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O Br     OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              H        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             H        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCF.sub.2 H                                                                           OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                      CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                         CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O Cl     OC.sub.2 H.sub.5                                                                        CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCF.sub.2 H                                                                           CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               N                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             cyclo-   N                                                                     propyl                                             --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              CH.sub.3 N                                         --C(OCH.sub.3)(OCH.sub.2 H.sub.5).sub.2                                                    H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        2-ethoxy-1,3-                                                                              H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O Cl     OCH.sub.3                                                                               CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         --C(n-C.sub.3 H.sub.7)(OCH.sub.3).sub.2                                                    H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        2-ethyl-1,3-                                                                               H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dioxolan-2-y1                                                                  2-ethyl-1,3-                                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  2-ethyl-1,3-                                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             C.tbd.CH CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             CF.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             SCF.sub.2 H                                                                             CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.2 F                                                                            OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             H        CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        CH                                        C(OCH.sub.3).sub.3                                                                         H   H  O F      OCH.sub.3                                                                               CH                                        C(OCH.sub.3).sub.3                                                                         H   H  O I      OCH.sub.3                                                                               CH                                        C(OCH.sub.3).sub.3                                                                         H   H  O OCH.sub.3                                                                             C.tbd.CH CH                                        __________________________________________________________________________

                                      TABLE Ia                                     __________________________________________________________________________     GENERAL STRUCTURE Ia                                                           R.sub.1     R.sub.12                                                                          R  W X      Y        Z m.p. °C.                          __________________________________________________________________________     1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O Cl     OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCF.sub.2 H                                                                           CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CH.sub.2 F                                                                  CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CHF.sub.2                                                                   CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CF.sub.3                                                                    CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          H  H  O CF.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CF.sub.3                                                                              OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              NHCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             N(CH.sub.3).sub.2                                                                       N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             N(CH.sub.3)OCH.sub.3                                                                    N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                      N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              SCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 CH═CH.sub.2                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 C.tbd.CH                                                                      N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.2 CH.sub.3                                                             N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.2 OC.sub.2 H.sub.5                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                            CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                            N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                      N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                      CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH(OCH.sub.3).sub.2                                                                     CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              i-C.sub.3 H.sub.7                                                                       CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH(OCH.sub.3).sub.2                                                                     N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-dioxolan-2-yl                                                                       CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-dioxolan-2-yl                                                                       N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             4-methyl-1,3-                                                                           N                                                                     dioxolan-2-yl                                       1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             4-methyl-1,3-                                                                           CH                                                                    dioxolan-2-yl                                       1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             4-ethyl-1,3-                                                                            CH                                                                    dioxolan-2-yl                                       1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-dioxan-2-yl                                                                         N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-dioxan-2-yl                                                                         CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             cyclopropyl                                                                             CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                         1,3-dioxolan-2-yl                                                                          H  H  O Br     OCF.sub.2 H                                                                             CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             cyclopropyl                                                                             N                                          1,3-dioxolan-2-yl                                                                          H  H  O F      CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O F      OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O Br     OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O Br     CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O I      OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             cyclopropyl                                                                             CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CH.sub.3                                                                    cyclopropyl                                                                             N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CH.sub.2 F                                                                  cyclopropyl                                                                             N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             cyclopropyl                                                                             N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH(SCH.sub.3).sub.2                                                                     N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH(SCH.sub.3).sub.2                                                                     CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-dithiolan-2-yl                                                                      CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-dithiolan-2-yl                                                                      N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-oxathiolan-2-yl                                                                     N                                          1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O Cl     OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  S CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  S CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  S OCH.sub.3                                                                             CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          H  H  S OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                         H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                         H  H  O Cl     OCH.sub.3                                                                               CH                                         1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                              N                                          1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                              N                                          --CH(OCH.sub. 3).sub.2                                                                     H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --CH(OCH.sub.3).sub.2                                                                      H  H  O CH.sub.3                                                                              CH.sub.3 N                                          --CH(OCH.sub.3).sub.2                                                                      H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --CH(OCH.sub.3).sub.2                                                                      H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --CH(OCH.sub.3).sub.2                                                                      H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --CH(OCH.sub.3).sub.2                                                                      H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --CH(OCH.sub.3).sub.2                                                                      H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O CH.sub.3                                                                              CH.sub.3 N                                          --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O Cl     OCH.sub.3                                                                               CH                                         --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O CH.sub.3                                                                              CH.sub.3 N                                          --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --CH(SCH.sub.3).sub.2                                                                      H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --CH(SCH.sub.3).sub.2                                                                      H  H  O CH.sub.3                                                                              CH.sub.3 N                                          --CH(SCH.sub.3).sub.2                                                                      H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --CH(SCH.sub.3).sub.2                                                                      H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --CH(SCH.sub.3).sub.2                                                                      H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              CH.sub.3 N                                          dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O Cl     OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O Br     OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                              N                                          dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              CH.sub.3 N                                          dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O Cl     OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O Br     OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  1,3-oxathiolan-2-yl                                                                        H  H  O OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                              N                                          1,3-oxathiolan-2-yl                                                                        H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-oxathiolan-2-yl                                                                        H  H  O CH.sub.3                                                                              CH.sub.3 N                                          1,3-oxathiolan-2-yl                                                                        H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          1,3-oxathiolan-2-yl                                                                        H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         1,3-oxathiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-oxathiolan-2-yl                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-oxathiolan-2-yl                                                                        H  H  O Cl     OCH.sub.3                                                                               CH                                         1,3-oxathiolan-2-yl                                                                        H  H  O OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                              N                                          2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              CH.sub.3 N                                          dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         dithiolan-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O CH.sub.3                                                                              CH.sub.3 N                                          pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          pyrimidin-2-yl                                                                 4,5-dimethyl-1,3-                                                                          H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O CH.sub.3                                                                              CH.sub.3 N                                          dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              CH.sub.3 N                                          dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  1,3-dimethyl-2-                                                                            H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O CH.sub.3                                                                              CH.sub.3 N                                          imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         imidazolinyl                                                                   1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3 N                                          --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O Br     OCH.sub. 3                                                                              CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              H        CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             H        CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O OCF.sub.2 H                                                                           OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                      CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                         CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O Cl     OC.sub.2 H.sub.5                                                                        CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                                          --C(OCH.sub.3).sub.3                                                                       H  H  O OCF.sub.2 H                                                                           CH.sub.3 CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               N                                          --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             cyclo-   N                                                                     propyl                                              --C(OCH.sub.3).sub.3                                                                       H  H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              CH.sub.3 N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O Br     OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              H        CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             H        CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                               CH                                         --C(OC.sub.2 H.sub.5 ).sub.3                                                               H  H  O OCF.sub.2 H                                                                           OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                      CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                         CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O Cl     OC.sub.2 H.sub.5                                                                        CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                              N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCF.sub.2 H                                                                           CH.sub.3 CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CF.sub.2 H                                                                            OCH.sub.3                                                                               N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             cyclo-   N                                                                     propyl                                              --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              CH.sub.3 N                                          --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(C.sub.2 H.sub.5)(OCH.sub. 3).sub.2                                                     H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(n-C.sub.3 H.sub.7)(OCH.sub.3).sub.2                                                    H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         2-ethyl-1,3-                                                                               H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  1,3-dioxolan-2-yl                                                                          C.sub.2 H.sub.5                                                                   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          Cl H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         __________________________________________________________________________

                                      TABLE Ib                                     __________________________________________________________________________     GENERAL STRUCTURE Ib                                                           R.sub.1     R.sub.12                                                                          R  W  X       Y         Z  m.p. ° C.                     __________________________________________________________________________     1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       1,3-dioxolan-2-yl                                                                          H  H  O  Cl      OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                                                               N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCF.sub.2 H                                                                            CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CF.sub.2 H                                                                             OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CF.sub.2 H                                                                             OCH.sub.3 N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.2 CH.sub.2 F                                                                   CH.sub.3  N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.2 CHF.sub.2                                                                    CH.sub.3  N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.2 CF.sub.3                                                                     CH.sub.3  N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CF.sub.3                                                                               CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CF.sub.3                                                                               OCH.sub.3 N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               NHCH.sub.3                                                                               N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              N(CH.sub.3).sub.2                                                                        N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              N(CH.sub.3)OCH.sub.3                                                                     N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                       N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               CH.sub.2 OCH.sub.3                                                                       CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               SCH.sub.3 N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               OCH.sub.2 CH═CH.sub.2                                                                N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               OCH.sub.2 C.tbd.CH                                                                       N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              CH.sub.2 OCH.sub.2 CH.sub.3                                                              N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               CH.sub.2 OC.sub.2 H.sub.5                                                                N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               OCH.sub.2 CH.sub.2 OCH.sub.3                                                             CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               OCH.sub.2 CH.sub.2 OCH.sub.3                                                             N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               CH.sub.2 SCH.sub.3                                                                       N                                       1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               CH.sub.2 SCH.sub.3                                                                       CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               CH(OCH.sub.3).sub.2                                                                      CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               i-C.sub.3 H.sub.7                                                                        CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  CH.sub.3                                                                               CH(OCH.sub.3).sub.2                                                                      N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              1,3-dioxolan-2-yl                                                                        CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              1,3-dioxolan-2-yl                                                                        N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              4-methyl-1,3-                                                                            N                                                                    dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              4-methyl-1,3-                                                                            CH                                                                   dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              4-ethyl-1,3-                                                                             CH                                                                   dioxolan-2-yl                                     1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              1,3-dioxol-2-yl                                                                          N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              1,3-dioxol-2-yl                                                                          CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              cyclopropyl                                                                              CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCF.sub.2 H                                                                            OCF.sub.2 H                                                                              CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  Br      OCF.sub.2 H                                                                              CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              cyclopropyl                                                                              N                                       1,3-dioxolan-2-yl                                                                          H  H  O  F       CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  F       OCH.sub.3 CH                                      l,3-dioxolan-2-yl                                                                          H  H  O  Br      OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  Br      CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  I       OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              cyclopropyl                                                                              CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.2 CH.sub.3                                                                     cyclopropyl                                                                              N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.2 CH.sub.2 F                                                                   cyclopropyl                                                                              N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              cyclopropyl                                                                              N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              CH(SCH.sub.3).sub.2                                                                      N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              CH(SCH.sub.3).sub.2                                                                      CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              1,3-dithiolan-2-yl                                                                       CH                                      1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              1,3-dithiolan-2-yl                                                                       N                                       1,3-dioxolan-2-yl                                                                          H  H  O  OCH.sub.3                                                                              1,3-oxathiolan-2-yl                                                                      N                                       1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O  OCH.sub.3                                                                              CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O  OCH.sub.3                                                                              OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O  CH.sub.3                                                                               CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O  CH.sub.3                                                                               CH.sub.3  N                                       1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O  CH.sub.3                                                                               OCH.sub.3 N                                       1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O  OCH.sub.3                                                                              OCH.sub.3 N                                       1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O  Cl      OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  H  S  CH.sub.3                                                                               OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          H  H  S  CH.sub.3                                                                               CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          H  H  S  OCH.sub.3                                                                              CH.sub.3  N                                       1,3-dioxolan-2-yl                                                                          H  H  S  OCH.sub.3                                                                              OCH.sub.3 N                                       1,3-dithiolan-2-yl                                                                         H  H  O  OCH.sub.3                                                                              CH.sub.3  CH                                      1,3-dithiolan-2-yl                                                                         H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      1,3-dithiolan-2-yl                                                                         H  H  O  Cl      OCH.sub.3 CH                                      1,3-dithiolan-2-yl                                                                         H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      1,3-dithiolan-2-yl                                                                         H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       1,3-dithiolan-2-yl                                                                         H  H  O  OCH.sub.3                                                                              CH.sub.3  N                                       1,3-dithiolan-2-yl                                                                         H  H  O  OCH.sub.2 CF.sub.3                                                                     NHCH.sub.3                                                                               N                                       1,3-dithiolan-2-yl                                                                         H  H  O  OCH.sub.2 CH.sub.2 F                                                                   NHCH.sub.3                                                                               N                                       --CH(OCH.sub.3).sub.2                                                                      H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      --CH(OCH.sub.3).sub.2                                                                      H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       --CH(OCH.sub.3).sub.2                                                                      H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       --CH(OCH.sub.3).sub.2                                                                      H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      --CH(OCH.sub.3).sub.2                                                                      H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      --CH(OCH.sub.3).sub.2                                                                      H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       --CH(OCH.sub.3).sub.2                                                                      H  H  O  Cl      OCH.sub.3 CH                                      --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       --C(CH.sub.3)(OCH.sub. 3).sub.2                                                            H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       --C(CH.sub.3)(OCH.sub.3).sub.2                                                             H  H  O  Cl      OCH.sub.3 CH                                      --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      --CH(OC.sub.2 H.sub.5).sub.2                                                               H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       --CH(SCH.sub.3).sub.2                                                                      H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      --CH(SCH.sub.3).sub.2                                                                      H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       --CH(SCH.sub.3).sub.2                                                                      H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       --CH(SCH.sub.3).sub.2                                                                      H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      --CH(SCH.sub.3).sub.2                                                                      H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       2-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O  Cl      OCH.sub.3 CH                                      dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O  Br      OCH.sub.3 CH                                      dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  OC.sub.2 H.sub.5                                                                       NHCH.sub.3                                                                               N                                       dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  Cl      OCH.sub.3 CH                                      dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O  Br      OCH.sub.3 CH                                      dioxolan-2-yl                                                                  1,3-oxathiolan-2-yl                                                                        H  H  O  OC.sub.2 H.sub.5                                                                       NHCH.sub.3                                                                               N                                       1,3-oxathiolan-2-yl                                                                        H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      1,3-oxathiolan-2-yl                                                                        H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       1,3-oxathiolan-2-yl                                                                        H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       1,3-oxathiolan-2-yl                                                                        H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      1,3-oxathiolan-2-yl                                                                        H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      1,3-oxathiolan-2-yl                                                                        H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       1,3-oxathiolan-2-yl                                                                        H  H  O  Cl      OCH.sub.3 CH                                      1,3-oxathiolan-2-yl                                                                        H  H  O  OC.sub.2 H.sub.5                                                                       NHCH.sub.3                                                                               N                                       2-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       dithiolan-2-yl                                                                             3                                                                  2-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      dithiolan-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       pyrimidin-2-yl                                                                 4,5-dimethyl-1,3-                                                                          H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       dixolan-2-yl                                                                   4,5-dimethyl-1,3-                                                                          H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      dioxolan-2-yl                                                                  1,3-dimethyl-2-                                                                            H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      imidazolinyl                                                                   1,3-dimethyl-2-                                                                            H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      imidazolinyl                                                                   1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O  CH.sub.3                                                                               CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O  OCH.sub.3                                                                              CH.sub.3  CH                                      1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O  OCH.sub.3                                                                              CH.sub.3  N                                       1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O  CH.sub.3                                                                               CH.sub.3  N                                       --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  Cl      OCH.sub.3 CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  Br      OCH.sub.3 CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  CH.sub.3                                                                               H         CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.3                                                                              H         CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.3                                                                              CH.sub.2 OC.sub.2 H.sub.5                                                                CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  OCF.sub.2 H                                                                            OCH.sub.3 CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.3                                                                              CH(OCH.sub.3).sub.2                                                                      CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  CH.sub.3                                                                               OC.sub.2 H.sub.5                                                                         CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  CH.sub.3                                                                               CH.sub.2 OCH.sub.3                                                                       CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                       CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.3                                                                              C.sub.2 H.sub.5                                                                          CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  Cl      OC.sub.2 H.sub.5                                                                         CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                                                               N                                       --C(OCH.sub.3).sub.3                                                                       H  H  O  OCF.sub.2 H                                                                            CH.sub.3  CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  CF.sub.2 H                                                                             OCH.sub.3 CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  CF.sub.2 H                                                                             OCH.sub.3 N                                       --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.3                                                                              cyclo-    N                                                                    propyl                                            --C(OCH.sub.3).sub.3                                                                       H  H  O  OCF.sub.2 H                                                                            OCF.sub.2 H                                                                              CH                                      --C(OCH.sub.3).sub.3                                                                       H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       --C(OCH.sub.3).sub.3                                                                       H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       --C(OCH.sub.3).sub.3                                                                       H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  Cl      OCH.sub.3 CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  Br      OCH.sub.3 CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CH.sub.3                                                                               H         CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.3                                                                              H         CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.3                                                                              CH.sub.2 OC.sub.2 H.sub.5                                                                CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCF.sub.2 H                                                                            OCH.sub.3 CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.3                                                                              CH(OCH.sub.3).sub.2                                                                      CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CH.sub.3                                                                               OC.sub.2 H.sub.5                                                                         CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CH.sub.3                                                                               CH.sub.2 OCH.sub.3                                                                       CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                       CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.3                                                                              C.sub.2 H.sub.5                                                                          CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  Cl      OC.sub.2 H.sub.5                                                                         CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.2 CH.sub.3                                                                     NHCH.sub.3                                                                               N                                       --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCF.sub.2 H                                                                            CH.sub.3  CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CF.sub.2 H                                                                             OCH.sub.3 CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CF.sub.2 H                                                                             OCH.sub.3 N                                       --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.3                                                                              cyclo-    N                                                                    propyl                                            --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCF.sub.2 H                                                                            OCF.sub.2 H                                                                              CH                                      --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O  CH.sub.3                                                                               CH.sub.3  N                                       -- C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                    H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O  Cl      OCH.sub.3 CH                                      --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O  CH.sub.3                                                                               CH.sub.3  CH                                      --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       --C(C.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                      H  H  O  OCH.sub.3                                                                              OCH.sub.3 N                                       --C( -n-C.sub.3 H.sub.7)(OCH.sub.3).sub.2                                                  H  H  O  OCH.sub. 3                                                                             OCH.sub.3 CH                                      2-ethyl-1,3-                                                                               H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      dioxolan-2-yl                                                                  2-ethyl-1,3-                                                                               H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      dioxolan-2-yl                                                                  2-ethyl-1,3-                                                                               H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H  H  O  OCH.sub.3                                                                              OCH.sub.3 CH                                      dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               OCH.sub.3 CH                                      dioxolan-2-yl                                                                  2-propyl-1,3-                                                                              H  H  O  CH.sub.3                                                                               OCH.sub.3 N                                       dioxolan-2-yl                                                                  __________________________________________________________________________

                                      TABLE Ic                                     __________________________________________________________________________     GENERAL STRUCTURE Ic                                                           R.sub.1     R.sub.12                                                                           R  W X      Y        Z  m.p. °C.                        __________________________________________________________________________     1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O Cl     OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCF.sub.2 H                                                                           OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CH.sub.2 F                                                                  OC.sub.2 H.sub.5                                                                        N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CHF.sub.2                                                                   OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                              N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CF.sub.3                                                                    N(CH.sub.3).sub.2                                                                       N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                               N                                         1,3-dioxolan-2-yl                                                                          H   H  O CF.sub.3                                                                              OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O I      OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O Br     OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O F      OCH.sub.3                                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                      CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             NHCH.sub.3                                                                              CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             N(OCH.sub.3)CH.sub.3                                                                    N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                         N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                            CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             cyclopropyl                                                                             N                                         1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             SCF.sub.2 H                                                                             CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             1,3-dioxolan-2-yl                                                                       CH                                        1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.2 C.tbd.CH                                                                      N                                         1,3-dioxolan-2-yl                                                                          H   H  O CH.sub.3                                                                              OCH.sub.2 CH═CH.sub.2                                                               CH                                        1,3-dioxolan-2-yl                                                                          H   H  O OCH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                               N                                         1,3-dioxolan-2-yl                                                                          4-CH.sub.3                                                                         H  O OCH.sub.3                                                                             CH.sub.3 N                                         1,3-dioxolan-2-yl                                                                          4-C.sub.2 H.sub.5                                                                  H  O OCH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          4-Cl                                                                               H  O OCH.sub.3                                                                             CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dioxolan-2-yl                                                                          H   H  S CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                         H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.3                                                                             CH.sub.3 CH                                        1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        1,3-dithiolan-2-yl                                                                         H   H  O Cl     OCH.sub.3                                                                               CH                                        1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         1,3-dithiolan-2-yl                                                                         H   H  O OCH.sub.3                                                                             CH.sub.3 N                                         CH(OCH.sub.3).sub.2                                                                        H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        CH(OCH.sub.3).sub.2                                                                        H   H  O OCH.sub.3                                                                             CH.sub.3 CH                                        CH(OCH.sub.3).sub.2                                                                        H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        CH(OCH.sub.3).sub.2                                                                        H   H  O Cl     OCH.sub.3                                                                               CH                                        CH(OCH.sub.3).sub.2                                                                        H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         CH(OCH.sub.3).sub.2                                                                        H   H  O OCH.sub.3                                                                             CH.sub.3 N                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        CH(OC.sub.2 H.sub.5).sub.2                                                                 H   H  O OCH.sub.3                                                                             CH.sub.3 CH                                        CH(OC.sub.2 H.sub.5).sub.2                                                                 H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        CH(OC.sub.2 H.sub.5).sub.2                                                                 H   H  O Cl     OCH.sub.3                                                                               CH                                        CH(OC.sub.2 H.sub.5).sub.2                                                                 H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H   H  O OCH.sub.3                                                                             CH.sub.3 N                                         CH(SCH.sub.3).sub.2                                                                        H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        CH(SCH.sub.3).sub.2                                                                        H   H  O OCH.sub.3                                                                             CH.sub.3 CH                                        CH(SCH.sub.3).sub.2                                                                        H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        CH(SCH.sub.3).sub.2                                                                        H   H  O Cl     OCH.sub.3                                                                               CH                                        CH(SCH.sub.3).sub.2                                                                        H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         CH(SCH.sub.3).sub.2                                                                        H   H  O OCH.sub.3                                                                             CH.sub.3 N                                         C(CH.sub.3)(OCH.sub.3).sub.2                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        C(CH.sub.3)(OCH.sub.3).sub.2                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         C(CH.sub.3)(SCH.sub.3).sub.2                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        C(CH.sub.3)(SCH.sub.3).sub.2                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  1,3-oxathiolan-2-yl                                                                        H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        1,3-oxathiolan-2-yl                                                                        H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dithiolan-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         pyrimidin-2-yl                                                                 4,5-dimethyl-1,3-                                                                          H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         dioxolan-2-yl                                                                  1,3-dimethyl-2-                                                                            H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        imidazolidinyl                                                                 1,3-dimethyl-2-                                                                            H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         imidazolidinyl                                                                 --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O Cl     OCH.sub.3                                                                               CH                                        --C(OCH.sub.3).sub.3                                                                       H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --C(OCH.sub.3).sub.3                                                                       H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O Cl     OCH.sub.3                                                                               CH                                        --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O CH.sub.3                                                                              CH.sub.3 CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O Cl     OCH.sub.3                                                                               CH                                        --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H   H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                         __________________________________________________________________________

                                      TABLE Id                                     __________________________________________________________________________     GENERAL STRUCTURE Id                                                           R.sub.1     R.sub.12                                                                          R  W X      Y        Z  m.p. °C.                         __________________________________________________________________________     1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O Cl     OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCF.sub.2 H                                                                           OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CH.sub.2 F                                                                  OC.sub.2 H.sub.5                                                                        N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CHF.sub.2                                                                   OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CF.sub.3                                                                    N(CH.sub.3).sub.2                                                                       N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O CF.sub.3                                                                              OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O I      OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O Br     OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O F      OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                      CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             NHCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             N(OCH.sub.3)CH.sub.3                                                                    N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                         N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                            CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             cyclopropyl                                                                             N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             SCF.sub.2 H                                                                             CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-dioxolan-2-yl                                                                       CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 C.tbd.CH                                                                      N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 CH═CH.sub.2                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                               N                                          1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          C.sub.2 H.sub.5                                                                   H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          Cl H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  S CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                         H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dithiolan-2-yl                                                                         H  H  O Cl     OCH.sub.3                                                                               CH                                         1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          CH(OCH.sub.3).sub.2                                                                        H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         CH(OCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         CH(OCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CH(OCH.sub.3).sub.2                                                                        H  H  O Cl     OCH.sub.3                                                                               CH                                         CH(OCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          CH(OCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O Cl     OCH.sub.3                                                                               CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          CH(SCH.sub.3).sub.2                                                                        H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         CH(SCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         CH(SCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CH(SCH.sub.3).sub.2                                                                        H  H  O Cl     OCH.sub.3                                                                               CH                                         CH(SCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          CH(SCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          C(CH.sub.3)(OCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         C(CH.sub.3)(OCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              i-C.sub.3 H.sub.7                                                                       CH                                         C(CH.sub.3)(OCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          C(CH.sub.3)(SCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         C(CH.sub.3)(SCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O CH.sub. 3                                                                             OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  1,3-oxathiolan-2-yl                                                                        H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         1,3-oxathiolan-2-yl                                                                        H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dithiolan-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O CH.sub.2                                                                              OCH.sub.3                                                                               N                                          pyrimidin-2-yl                                                                 4,5-dimethyl-1,3-                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  1,3-dimethyl-2-                                                                            H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         imidazolidinyl                                                                 1,3-dimethyl-2-                                                                            H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          imidazolidinyl                                                                 --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          __________________________________________________________________________

                                      TABLE Ie                                     __________________________________________________________________________     GENERAL STRUCTURE Ie                                                           R.sub.1     R.sub.12                                                                          R  W K      Y        Z  m.p. °C.                         __________________________________________________________________________     1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O Cl     OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCF.sub.2 H                                                                           OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CH.sub.2 F                                                                  OC.sub.2 H.sub.5                                                                        N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CHF.sub.2                                                                   OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                              N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CF.sub.3                                                                    N(CH.sub.3).sub.2                                                                       N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                               N                                          1,3-dioxolan-2-yl                                                                          H  H  O CF.sub.3                                                                              OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O I      OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O Br     OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O F      OCH.sub.3                                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                      CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             NHCH.sub.3                                                                              CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             N(OCH.sub.3)CH.sub.3                                                                    N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                         N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 CH.sub.2 OCH.sub.3                                                            CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             cyclopropyl                                                                             N                                          1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             SCF.sub.2 H                                                                             CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             1,3-dioxolan-2-yl                                                                       CH                                         1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 .tbd.CH                                                                       N                                          1,3-dioxolan-2-yl                                                                          H  H  O CH.sub.3                                                                              OCH.sub.2 CH═CH.sub.2                                                               CH                                         1,3-dioxolan-2-yl                                                                          H  H  O OCH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                               N                                          1,3-dioxolan-2-yl                                                                          CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3 N                                          1,3-dioxolan-2-yl                                                                          C.sub.2 H.sub.5                                                                   H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          Cl H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dioxolan-2-yl                                                                          H  H  S CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                         H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         1,3-dithiolan-2-yl                                                                         H  H  O Cl     OCH.sub.3                                                                               CH                                         1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          1,3-dithiolan-2-yl                                                                         H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          CH(OCH.sub.3).sub.2                                                                        H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         CH(OCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                      CH.sub.3                                                                              CH                                                  CH(OCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CH(OCH.sub.3).sub.2                                                                        H  H  O Cl     OCH.sub.3                                                                               CH                                         CH(OCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          CH(OCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O Cl     OCH.sub.3                                                                               CH                                         CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          CH(OC.sub.2 H.sub.5).sub.2                                                                 H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          CH(SCH.sub.3).sub.2                                                                        H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         CH(SCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             CH.sub.3 CH                                         CH(SCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         CH(SCH.sub.3).sub.2                                                                        H  H  O Cl     OCH.sub.3                                                                               CH                                         CH(SCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          CH(SCH.sub.3).sub.2                                                                        H  H  O OCH.sub.3                                                                             CH.sub.3 N                                          C(CH.sub.3)(OCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         C(CH.sub.3)(OCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          C(CH.sub.3)(SCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         C(CH.sub.3)(SCH.sub.3).sub.2                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          2-methyl-1.3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  1,3-oxathiolan-2-yl                                                                        H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         1,3-oxathiolan-2-yl                                                                        H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dithiolan-2-yl                                                                 2-methyl-1,3-                                                                              H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dithiolan-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         pyrimidin-2-yl                                                                 hexahydro-1,3-dimethyl-                                                                    H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          pyrimidin-2-yl                                                                 4,5-dimethyl-1,3-                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4,5-dimethyl-1,3-                                                                          H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         dioxolan-2-yl                                                                  4-ethyl-1,3-                                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          dioxolan-2-yl                                                                  1,3-dimethyl-2-                                                                            H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         imidazolidinyl                                                                 1,3-dimethyl-2-                                                                            H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          imidazolidinyl                                                                 --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OCH.sub.3).sub.3                                                                       H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OCH.sub.3).sub.3                                                                       H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         -- C(OC.sub.2 H.sub.5).sub.3                                                               H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OC.sub.2 H.sub.T).sub.3                                                                H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OC.sub.2 H.sub.5).sub.3                                                                H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.2                                                     H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                              CH.sub.3 CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.2                                                     H  H  O Cl     OCH.sub.3                                                                               CH                                         --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.2                                                     H  H  O CH.sub.3                                                                              OCH.sub.3                                                                               N                                          --C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.2                                                     H  H  O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                          __________________________________________________________________________

                                      TABLE II                                     __________________________________________________________________________     General structure II                                                           R.sub.1  R.sub.11                                                                           R  W X      Y      Z  m.p. °C.                             __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             N                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             N                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                            N                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                            N                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                    CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.3                                                                             cyclo- CH                                                                      propyl                                                1,3-dioxolan-2-yl                                                                       C.sub.3 H.sub.7                                                                    H  O OCH.sub.3                                                                             CH.sub.3                                                                              CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  S CH.sub.3                                                                              CH.sub.3                                                                              CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.3                                                                              CH                                             CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.3                                                                              N                                              CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.3                                                                              CH                                             1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.3                                                                              N                                              1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             N                                              --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             N                                              --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             N                                              --C(OC.sub.2 H.sub.t).sub.3                                                             CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             N                                              __________________________________________________________________________

                                      TABLE IIa                                    __________________________________________________________________________     General structure Ila                                                          R.sub.1  R.sub.11                                                                           R  W X      Y      Z  m.P. °C.                             __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             N                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             N                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                            N                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                            N                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                    CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  O OCH.sub.3                                                                             cyclo- CH                                                                      propyl                                                1,3-dioxolan-2-yl                                                                       C.sub.3 H.sub.7                                                                    H  O OCH.sub.3                                                                             CH.sub.3                                                                              CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           H  S CH.sub.3                                                                              CH.sub.3                                                                              CH                                             1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.3                                                                              CH                                             CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.3                                                                              N                                              CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             CH(OCH.sub.3).sub.2                                                                     CH.sub.                                                                            H  O Cl     OCH.sub.3                                                                             CH                                             1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.3                                                                              CH                                             1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                           H  O OCH.sub.3                                                                             CH.sub.3                                                                              N                                              1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             1.3-dithiolan-2-yl                                                                      CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             N                                              --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             N                                              --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                             --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O CH.sub.3                                                                              CH                                                    --C(OC.sub.2 H.sub.5 ).sub.3                                                            CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O CH.sub.3                                                                              CH.sub.3                                                                              CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O Cl     OCH.sub.3                                                                             CH                                             --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O CH.sub.3                                                                              OCH.sub.3                                                                             N                                              --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                           H  O OCH.sub.3                                                                             OCH.sub.3                                                                             N                                              __________________________________________________________________________

                                      TABLE IIb                                    __________________________________________________________________________     General Structure IIb                                                          R.sub.1  R.sub.11                                                                          R  W X      Y     Z  m.p. °C.                               __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                           N                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                           N                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                   CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.3                                                                             cyclo-                                                                               CH                                                                       propyl                                                 1,3-dioxolan-2-yl                                                                       C.sub.3 H.sub.7                                                                   H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  S CH.sub.3                                                                              CH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                               CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3                                                                             N                                                CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                               1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3                                                                             N                                                1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub. 3                                                                            CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                __________________________________________________________________________

                                      TABLE IIc                                    __________________________________________________________________________     General Structure IIc                                                          R.sub.1  R.sub.11                                                                          R  W X      Y     Z  m.p. °C.                               __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                           N                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                           N                                                1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                   CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  O OCH.sub.3                                                                             cyclo-                                                                               CH                                                                       propyl                                                 1,3-dioxolan-2-yl                                                                       C.sub.3 H.sub.7                                                                   H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H  S CH.sub.3                                                                              CH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                               CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3                                                                             N                                                CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               CH(OCH.sub.3).sub.2                                                                     CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                               1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H  O OCH.sub.3                                                                             CH.sub.3                                                                             N                                                1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                --C(OCH.sub.3).sub.3                                                                    CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O CH.sub.3                                                                              CH.sub. 3                                                                            CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O Cl     OCH.sub.3                                                                            CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                --C(OC.sub.2 H.sub.5).sub.3                                                             CH.sub.3                                                                          H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                __________________________________________________________________________

                                      TABLE III                                    __________________________________________________________________________     General Structure III                                                          R.sub.1   R  W  X      Y      Z  m.p. °C.                               __________________________________________________________________________     1,3-dioxolan-2-yl                                                                        H  O  CH.sub.3                                                                              CH.sub.3                                                                              CH                                               1,3-dioxolan-2-yl                                                                        H  O  CH.sub.3                                                                              OCH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                        H  O  OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                        H  O  Cl     OCH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                        H  O  CH.sub.3                                                                              OCH.sub.3                                                                             N                                                1,3-dioxolan-2-yl                                                                        H  O  OCH.sub.3                                                                             OCH.sub.3                                                                             N                                                1,3-dioxolan-2-yl                                                                        H  O  OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                            N                                                1,3-dioxolan-2-yl                                                                        H  O  OCH.sub.2 CH.sub.3                                                                    NHCH.sub.3                                                                            N                                                1,3-dioxolan-2-yl                                                                        H  O  OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                    CH                                               1,3-dioxolan-2-yl                                                                        H  O  OCH.sub.3                                                                             cyclo- CH                                                                      propyl                                                  1,3-dioxolan-2-yl                                                                        H  O  OCH.sub.3                                                                             CH.sub.3                                                                              CH                                               1,3-dioxolan-2-yl                                                                        H  S  CH.sub.3                                                                              CH.sub.3                                                                              CH                                               1,3-dioxolan-2-yl                                                                        CH.sub.3                                                                          O  CH.sub.3                                                                              CH.sub.3                                                                              CH                                               CH(OCH.sub.3).sub.2                                                                      H  O  OCH.sub.3                                                                             CH.sub.3                                                                              CH                                               CH(OCH.sub.3).sub.2                                                                      H  O  OCH.sub.3                                                                             CH.sub.3                                                                              N                                                CH(OCH.sub.3).sub.2                                                                      H  O  CH.sub.3                                                                              CH.sub.3                                                                              CH                                               CH(OCH.sub.3).sub.2                                                                      H  O  Cl     OCH.sub.3                                                                             CH                                               1,3-dithiolan-2-yl                                                                       H  O  OCH.sub.3                                                                             CH.sub.3                                                                              CH                                               1,3-dithiolan-2-yl                                                                       H  O  OCH.sub.3                                                                             CH.sub.3                                                                              N                                                1,3-dithiolan-2-yl                                                                       H  O  CH.sub.3                                                                              CH.sub.3                                                                              CH                                               1,3-dithiolan-2-yl                                                                       H  O  Cl     OCH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                     H  O  OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                     H  O  CH.sub.3                                                                              OCH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                     H  O  CH.sub.3                                                                              CH.sub.3                                                                              CH                                               --C(OCH.sub.3).sub.3                                                                     H  O  Cl     OCH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                     H  O  CH.sub.3                                                                              OCH.sub.3                                                                             N                                                --C(OCH.sub.3).sub.3                                                                     H  O  OCH.sub.3                                                                             OCH.sub.3                                                                             N                                                --C(OC.sub.2 H.sub.5).sub.3                                                              H  O  OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                              H  O  CH.sub.3                                                                              OCH.sub.3                                                                             CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                              H  O  CH.sub.3                                                                              CH.sub.3                                                                              CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                              H  O  Cl     OCH.sub.3                                                                             CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                              H  O  CH.sub.3                                                                              OCH.sub.3                                                                             N                                                --C(OC.sub.2 H.sub.5).sub.3                                                              H  O  OCH.sub.3                                                                             OCH.sub.3                                                                             N                                                __________________________________________________________________________

                                      TABLE IIIa                                   __________________________________________________________________________     General Structure IIIa                                                         R.sub.1  R   W X       Y      Z  m.p. °C.                               __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       H   O CH.sub.3                                                                               CH.sub.3                                                                              CH                                               1,3-dioxolan-2-yl                                                                       H   O CH.sub.3                                                                               OCH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       H   O OCH.sub.3                                                                              OCH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       H   O Cl      OCH.sub.3                                                                             CH                                               1,3-dioxolan-2-yl                                                                       H   O CH.sub.3                                                                               OCH.sub.3                                                                             N                                                1,3-dioxolan-2-yl                                                                       H   O OCH.sub.3                                                                              OCH.sub.3                                                                             N                                                1,3-dioxolan-2-yl                                                                       H   O OCH.sub.2 CH.sub.2 F                                                                   NHCH.sub.3                                                                            N                                                1,3-dioxolan-2-yl                                                                       H   O OCH.sub.2 CF.sub.3                                                                     NHCH.sub.3                                                                            N                                                1,3-dioxolsn-2-yl                                                                       H   O OCH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                    CH                                               1,3-dioxolan-2-yl                                                                       H   O OCH.sub.3                                                                              cyclo- CH                                                                      propyl                                                  1,3-dioxolan-2-yl                                                                       H   O OCH.sub.3                                                                              CH.sub.3                                                                              CH                                               1,3-dioxolan-2-yl                                                                       H   S CH.sub.3                                                                               CH.sub.3                                                                              CH                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                           O CH.sub.3                                                                               CH.sub.3                                                                              CH                                               CH(OCH.sub.3).sub.2                                                                     H   O OCH.sub.3                                                                              CH.sub.3                                                                              CH                                               CH(OCH.sub.3).sub.2                                                                     H   O OCH.sub.3                                                                              CH.sub.3                                                                              N                                                CH(OCH.sub.3).sub.2                                                                     H   O CH.sub.3                                                                               CH.sub.3                                                                              CH                                               CH(OCH.sub.3).sub.2                                                                     H   O Cl      OCH.sub.3                                                                             CH                                               1,3-dithiolan-2-yl                                                                      H   O OCH.sub.3                                                                              CH.sub.3                                                                              CH                                               1,3-dithiolan-2-yl                                                                      H   O OCH.sub.3                                                                              CH.sub.3                                                                              N                                                1,3-dithiolan-2-yl                                                                      H   O CH.sub.3                                                                               CH.sub.3                                                                              CH                                               1,3-dithiolan-2-yl                                                                      H   O Cl      OCH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                    H   O OCH.sub.3                                                                              OCH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                    H   O CH.sub.3                                                                               OCH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                    H   O CH.sub.3                                                                               CH.sub.3                                                                              CH                                               --C(OCH.sub.3).sub.3                                                                    H   O Cl      OCH.sub.3                                                                             CH                                               --C(OCH.sub.3).sub.3                                                                    H   O CH.sub.3                                                                               OCH.sub.3                                                                             N                                                --C(OCH.sub.3).sub.3                                                                    H   O OCH.sub.3                                                                              OCH.sub.3                                                                             N                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H   O OCH.sub.3                                                                              OCH.sub.3                                                                             CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H   O CH.sub.3                                                                               OCH.sub.3                                                                             CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H   O CH.sub.3                                                                               CH.sub.3                                                                              CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H   O Cl      OCH.sub.3                                                                             CH                                               --C(OC.sub.2 H.sub.5).sub.3                                                             H   O CH.sub.3                                                                               OCH.sub.3                                                                             N                                                --C(OC.sub.2 H.sub.5).sub.3                                                             H   O OCH.sub.3                                                                              OCH.sub.3                                                                             N                                                __________________________________________________________________________

                                      TABLE IIIb                                   __________________________________________________________________________     General structure IIIb                                                         R.sub.1  R  W X      Y     Z  m.p. °C.                                  __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                                  1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                                  1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                                  1,3-dioxolan-2-yl                                                                       H  O Cl     OCH.sub.3                                                                            CH                                                  1,3-dioxolan-2-yl                                                                       H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                   1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                   1,3-dioxolan-2-yl                                                                       H  O OCH.sub.2 CH.sub.2 F                                                                  NHCH.sub.3                                                                           N                                                   1,3-dioxolan-2-yl                                                                       H  O OCH.sub.2 CF.sub.3                                                                    NHCH.sub.3                                                                           N                                                   1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                   CH                                                  1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                             cyclo-                                                                               CH                                                                       propyl                                                    1,3-dioxolan-2-yl                                                                       H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                                  1,3-dioxolan-2-yl                                                                       H  S CH.sub.3                                                                              CH.sub.3                                                                             CH                                                  1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          O CH.sub.3                                                                              CH.sub.3                                                                             CH                                                  CH(OCH.sub.3).sub.2                                                                     H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                                  CH(OCH.sub.3).sub.2                                                                     H  O OCH.sub.3                                                                             CH.sub.3                                                                             N                                                   CH(OCH.sub.3).sub.2                                                                     H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                                  CH(OCH.sub.3).sub.2                                                                     H  O Cl     OCH.sub.3                                                                            CH                                                  1,3-dithiolan-2-yl                                                                      H  O OCH.sub.3                                                                             CH.sub.3                                                                             CH                                                  1,3-dithiolan-2-yl                                                                      H  O OCH.sub.3                                                                             CH.sub.3                                                                             N                                                   1,3-dithiolan-2-yl                                                                      H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                                  1,3-dithiolan-2-yl                                                                      H  O Cl     OCH.sub.3                                                                            CH                                                  --C(OCH.sub.3).sub.3                                                                    H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                                  --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                                  --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                                  --C(OCH.sub.3).sub.3                                                                    H  O Cl     OCH.sub.3                                                                            CH                                                  --C(OCH.sub.3).sub.3                                                                    H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                   --C(OCH.sub.3).sub.3                                                                    H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                   --C(OC.sub.2 H.sub.5).sub.3                                                             H  O OCH.sub.3                                                                             OCH.sub.3                                                                            CH                                                  --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                              OCH.sub.3                                                                            CH                                                  --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                              CH.sub.3                                                                             CH                                                  --C(OC.sub.2 H.sub.5).sub.3                                                             H  O Cl     OCH.sub.3                                                                            CH                                                  --C(OC.sub.2 H.sub.5).sub.3                                                             H  O CH.sub.3                                                                              OCH.sub.3                                                                            N                                                   --C(OC.sub.2 H.sub.5).sub.3                                                             H  O OCH.sub.3                                                                             OCH.sub.3                                                                            N                                                   __________________________________________________________________________

                                      TABLE IV                                     __________________________________________________________________________     General Structure IV                                                           R.sub.1  R.sub.2                                                                          R W W.sub.1                                                                           A  X.sub.1                                                                              Y.sub.1                                                                            Y.sub.2                                                                           m.p. °C.                              __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       H H O S  A-2                                                                               CH.sub.3                                                                             O   --                                              1,3-dioxolan-2-yl                                                                       H H O S  A-2                                                                               OCH.sub.3                                                                            O   --                                              1,3-dioxolan-2-yl                                                                       H H O S  A-2                                                                               OCF.sub.2 H                                                                          O   --                                              1,3-dioxolan-2-yl                                                                       H H O S  A-2                                                                               CH.sub.3                                                                             CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                       H H O S  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                       H H O S  A-2                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                       H H O O  A-2                                                                               CH.sub.3                                                                             O   --                                              1,3-dioxolan-2-yl                                                                       H H O O  A-2                                                                               OCH.sub.3                                                                            O   --                                              1,3-dioxolan-2-yl                                                                       H H O O  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dithiolan-2-yl                                                                      H H O S  A-2                                                                               CH.sub.3                                                                             O   --                                              1,3-dithiolan-2-yl                                                                      H H O S  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dithiolan-2-yl                                                                      H H O O  A-2                                                                               CH.sub.3                                                                             O   --                                              1,3-dithiolan-2-yl                                                                      H H O O  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                           --                                              CH(OCH.sub.3 ).sub.2                                                                    H H O S  A-2                                                                               CH.sub.3                                                                             O   --                                              CH(OCH.sub.3).sub.2                                                                     H H O O  A-2                                                                               CH.sub.3                                                                             O   --                                              1,3-dioxolan-2-yl                                                                       H H O S  A-3                                                                               CH.sub.3                                                                             --  --                                              1,3-dioxolan-2-yl                                                                       H H O S  A-3                                                                               OCH.sub.3                                                                            --  --                                              1,3-dioxolan-2-yl                                                                       H H O O  A-3                                                                               OCF.sub.2 H                                                                          --  --                                              1,3-dioxolan-2-yl                                                                       H H O S  A-4                                                                               OCH.sub.3                                                                            --  CH.sub.3                                        1,3-dioxolan-2-yl                                                                       H H O S  A-4                                                                               CH.sub.3                                                                             --  CH.sub.3                                        1,3-dioxolan-2-yl                                                                       H H O S  A-4                                                                               OC.sub.2 H.sub.5                                                                     --  H                                               1,3-dioxolan-2-yl                                                                       H H O O  A-4                                                                               CH.sub.3                                                                             --  CH.sub.3                                        1,3-dioxolan-2-yl                                                                       H H O O  A-4                                                                               OCF.sub.2 H                                                                          --  CH.sub.3                                        1,3-dithiolan-2-yl                                                                      H H O S  A-3                                                                               CH.sub.3                                                                             --  --                                              1,3-dithiolan-2-yl                                                                      H H O S  A-4                                                                               CH.sub.3                                                                             --  CH.sub.3                                        CH(OCH.sub.3).sub.2                                                                     H H O S  A-3                                                                               OCH.sub.3                                                                            --  --                                              CH(OCH.sub.3).sub.2                                                                     H H O S  A-4                                                                               OCH.sub.3                                                                            --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                      H H O S  A-2                                                                               CH.sub.3                                                                             O   --                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-2                                                                               OCH.sub.3                                                                            O   --                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-2                                                                               OCF.sub.2 H                                                                          O   --                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-2                                                                               CH.sub.3                                                                             CH.sub.2                                                                           --                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                           --                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-2                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                           --                                              C(OCH.sub.3).sub.3                                                                      H H O O  A-3                                                                               CH.sub.3                                                                             --  --                                              C(OCH.sub.3).sub.3                                                                      H H O O  A-3                                                                               OCH.sub.3                                                                            --  --                                              C(OCH.sub.3).sub.3                                                                      H H O O  A-3                                                                               OCF.sub.2 H                                                                          --  --                                              C(OCH.sub.3).sub.3                                                                      H H O O  A-4                                                                               OCH.sub.3                                                                            --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                      H H O O  A-4                                                                               CH.sub.3                                                                             --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                      H H O O  A-4                                                                               OC.sub.2 H.sub.5                                                                     --  H                                               C(OCH.sub.3).sub.3                                                                      H H O O  A-4                                                                               OCF.sub.2 H                                                                          --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                      H H O O  A-2                                                                               CH.sub.3                                                                             O   --                                              C(OC.sub.2 H.sub.5).sub.3                                                               H H O O  A-2                                                                               CH.sub.3                                                                             O   --                                              C(OC.sub.2 H.sub.5).sub.3                                                               H H O S  A-2                                                                               CH.sub.3                                                                             O   --                                              __________________________________________________________________________                          X.sub.2                                                                              Y.sub.3                                             __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                           C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                           C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.3                                                                             CH.sub.3                                            C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.3                                                                             C.sub.2 H.sub.5                                     C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                         C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                         C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               C.sub.2 H.sub.5                                                                      OCH.sub.3                                           C(OCH.sub.3).sub.3                                                                      H H O S  A-5                                                                               CH.sub.2 CF.sub.3                                                                    OCH.sub.3                                           C(OCH.sub.3).sub.3                                                                      H H O O  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                           __________________________________________________________________________                          X.sub.2                                                                              Y.sub. 3                                                                           --                                              __________________________________________________________________________     1,3-dioxolan-                                                                           H H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                          --                                              2-yl                                                                           1,3-dioxolan-                                                                           H H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                   --                                              2-yl                                                                           1,3-dioxolan-                                                                           H H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                                                          --                                              2-yl                                                                           1,3-dioxolan-                                                                           H H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                                                   --                                              2-yl                                                                           1,3-dioxolan-                                                                           H H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                                                        --                                              2-yl                                                                           1,3-dioxolan-                                                                           H H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                                                        --                                              2-yl                                                                           CH(OCH.sub.3).sub.2                                                                     H H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                          --                                              CH(OCH.sub.3).sub.2                                                                     H H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                   --                                              CH(OCH.sub.3).sub.2                                                                     H H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                                                          --                                              CH(OCH.sub.3).sub.2                                                                     H H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                                                   --                                              CH(OCH.sub.3).sub.2                                                                     H H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                                                        --                                              CH(OCH.sub.3).sub.2                                                                     H H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                                                        --                                              CH(OCH.sub.3).sub.2                                                                     H H O O  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                          --                                              __________________________________________________________________________                          X.sub.3                                                   __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                      H H O S  A-6                                                                               CH.sub.3                                                                             --  --                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-6                                                                               OCH.sub.3                                                                            --  --                                              1,3-dioxolan-                                                                           H H O S  A-6                                                                               CH.sub.3                                                                             --  --                                              2-yl                                                                           1,3-dioxolan-                                                                           H H O S  A-6                                                                               OCH.sub.3                                                                            --  --                                              2-yl                                                                           CH(OCH.sub.3).sub.2                                                                     H H O S  A-6                                                                               CH.sub.3                                                                             --  --                                              CH(OCH.sub.3).sub.2                                                                     H H O S  A-6                                                                               OCH.sub.3                                                                            --  --                                              CH(OCH.sub.3).sub.2                                                                     H H O O  A-6                                                                               CH.sub.3                                                                             --  --                                              __________________________________________________________________________                          X.sub.4                                                                              Y.sub.4                                                                            Z                                               __________________________________________________________________________     CH(OCH.sub.3).sub.2                                                                     H H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           CH                                              CH(OCH.sub.3).sub.2                                                                     H H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                          CH                                              1,3-dioxolan-                                                                           H H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           CH                                              2-yl                                                                           1,3-dioxolan-                                                                           H H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                          CH                                              2-yl                                                                           C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           CH                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           N                                               C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               OCH.sub.3                                                                            CH.sub.3                                                                           CH                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               OCH.sub.3                                                                            CH.sub.3                                                                           N                                               C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                          N                                               C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               Cl    CH.sub.3                                                                           CH                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               OCH.sub.3                                                                            Cl  CH                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.3                                                                           CH                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               CH.sub.2 OCH.sub.3                                                                   CH.sub.3                                                                           N                                               C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               CH.sub.2 OCH.sub.3                                                                   OCH.sub.3                                                                          CH                                              C(OCH.sub.3).sub.3                                                                      H H O S  A-7                                                                               OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                   N                                               C(OCH.sub.3).sub.3                                                                      H H O O  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           CH                                              __________________________________________________________________________

                                      TABLE IVa                                    __________________________________________________________________________     General Structure IVa                                                          __________________________________________________________________________     R.sub.1  R.sub.12                                                                          R W W.sub.1                                                                           A  X.sub.1                                                                              Y.sub.1                                                                            Y.sub.2                                                                            m.p. °C.                            __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               CH.sub.3                                                                             O   --                                             1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               OCH.sub.3                                                                            O   --                                             1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               OCF.sub.2 H                                                                          O   --                                             1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               CH.sub.3                                                                             CH.sub.2                                                                           --                                             1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                           --                                             1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                           --                                             1,3-dioxolan-2-yl                                                                       H  H O O  A-2                                                                               CH.sub.3                                                                             O   --                                             1,3-dioxolan-2-yl                                                                       H  H O O  A-2                                                                               OCH.sub.3                                                                            O   --                                             1,3-dioxolan-2-yl                                                                       H  H O O  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                           --                                             1,3-dithiolan-2-yl                                                                      H  H O S  A-2                                                                               CH.sub.3                                                                             O   --                                             1,3-dithiolan-2-yl                                                                      H  H O S  A-2                                                                               OCH.sub.3                                                                            CH  --                                             1,3-dithiolan-2-yl                                                                      H  H O O  A-2                                                                               CH.sub.3                                                                             O   --                                             1,3-dithiolan-2-yl                                                                      H  H O O  A-2                                                                               OCH.sub.3                                                                            CH  --                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-2                                                                               CH.sub.3                                                                             O   --                                             CH(OCH.sub.3).sub.2                                                                     H  H O O  A-2                                                                               CH.sub.3                                                                             O   --                                             1,3-dioxolan-2-yl                                                                       H  H O S  A-3                                                                               CH.sub.3                                                                             --  --                                             1,3-dioxolan-2-yl                                                                       H  H O S  A-3                                                                               OCH.sub.3                                                                            --  --                                             1,3-dioxolan-2-yl                                                                       H  H O O  A-3                                                                               OCF.sub.2 H                                                                          --  --                                             1,3-dioxolan-2-yl                                                                       H  H O S  A-4                                                                               OCH.sub.3                                                                            --  CH.sub.3                                       1,3-dioxolan-2-yl                                                                       H  H O S  A-4                                                                               CH.sub.3                                                                             --  CH.sub.3                                       1,3-dioxolan-2-yl                                                                       H  H O S  A-4                                                                               OC.sub.2 H.sub.5                                                                     --  H                                              1,3-dioxolan-2-yl                                                                       H  H O O  A-4                                                                               CH.sub.3                                                                             --  CH.sub.3                                       1,3-dioxolan-2-yl                                                                       H  H O O  A-4                                                                               OCF.sub.2 H                                                                          --  CH.sub.3                                       1,3-dithiolan-2-yl                                                                      H  H O S  A-3                                                                               CH.sub.3                                                                             --  --                                             1,3-dithiolan-2-yl                                                                      H  H O S  A-4                                                                               CH.sub.3                                                                             --  CH.sub.3                                       CH(OCH.sub.3).sub.2                                                                     H  H O S  A-3                                                                               OCH.sub.3                                                                            --  --                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-4                                                                               OCH.sub.3                                                                            --  CH.sub.3                                       C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               CH.sub.3                                                                             O   --                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               OCH.sub.3                                                                            O   --                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               OCF.sub.2 H                                                                          O   --                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               CH.sub.3                                                                             CH.sub.2                                                                           --                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                           --                                             C(OCH.sub.3).sub.2                                                                      H  H O S  A-2                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                           --                                             C(OCH.sub.3).sub.3                                                                      H  H O O  A-3                                                                               CH.sub.3                                                                             --  --                                             C(OCH.sub.3).sub.3                                                                      H  H O O  A-3                                                                               OCH.sub.3                                                                            --  --                                             C(OCH.sub.3).sub.3                                                                      H  H O O  A-3                                                                               OCF.sub.2 H                                                                          --  --                                             C(OCH.sub.3).sub.3                                                                      H  H O O  A-4                                                                               OCH.sub.3                                                                            --  CH.sub.3                                       C(OCH.sub.3).sub.3                                                                      H  H O O  A-4                                                                               CH.sub.3                                                                             --  CH.sub.3                                       C(OCH.sub.3).sub.3                                                                      H  H O O  A-4                                                                               OC.sub.2 H.sub.5                                                                     --  H                                              C(OCH.sub.3).sub.3                                                                      H  H O O  A-4                                                                               OCF.sub.2 H                                                                          --  CH.sub.3                                       C(OCH.sub.3).sub.3                                                                      H  H O O  A-2                                                                               CH.sub.3                                                                             O   --                                             C(OC.sub.2 H.sub.5).sub.3                                                               H  H O O  A-2                                                                               CH.sub.3                                                                             O   --                                             C(OC.sub.2 H.sub.5 ).sub.3                                                              H  H O S  A-2                                                                               CH.sub.3                                                                             O   --                                                                   X.sub.2                                                                              Y.sub.3                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             CH.sub.3                                           C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             C.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               C.sub.2 H.sub.5                                                                      OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.2 CF.sub.3                                                                    OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H  H O O  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                          1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                          --                                             2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                   --                                             2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                                                          --                                             2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                                                   --                                             2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                                                        --                                             2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                                                        --                                             2-yl                                                                           CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                          --                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                   --                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                                                          --                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                                                   --                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                                                        --                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                                                        --                                             CH(OCH.sub.3).sub.2                                                                     H  H O O  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                          --                                                                   X.sub.3                                                  C(OCH.sub.3).sub.3                                                                      H  H O S  A-6                                                                               CH.sub.3                                                                             --  --                                             C(OCH.sub.3 ).sub.3                                                                     H  H O S  A-6                                                                               OCH.sub.3                                                                            --  --                                             1,3-dioxolan-                                                                           H  H O S  A-6                                                                               CH.sub.3                                                                             --  --                                             2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-6                                                                               OCH.sub.3                                                                            --  --                                             2-yl                                                                           CH(OCH.sub.3).sub.2                                                                     H  H O S  A-6                                                                               CH.sub.3                                                                             --  --                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-6                                                                               OCH.sub.3                                                                            --  --                                             CH(OCH.sub.3).sub.2                                                                     H  H O O  A-6                                                                               CH.sub.3                                                                             --  --                                                                   X.sub.4                                                                              Y.sub.4                                                                            Z                                              CH(OCH.sub.3).sub.2                                                                     H  H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           CH                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                          CH                                             1,3-dioxolan-                                                                           H  H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           CH                                             2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                          CH                                             2-yl                                                                           C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           CH                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           N                                              C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OCH.sub.3                                                                            CH.sub.3                                                                           CH                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OCH.sub.3                                                                            CH.sub.3                                                                           N                                              C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                          N                                              C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               Cl    CH.sub.3                                                                           CH                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OCH.sub.3                                                                            Cl  CH                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.3                                                                           CH                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               CH.sub.2 OCH.sub.3                                                                   CH.sub.3                                                                           N                                              C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               CH.sub.2 OCH.sub.3                                                                   OCH.sub.3                                                                          CH                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                   N                                              C(OCH.sub.3).sub.3                                                                      H  H O O  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                           CH                                             __________________________________________________________________________

                                      TABLE IVb                                    __________________________________________________________________________     General Structure IVb                                                          __________________________________________________________________________     R.sub.1  R.sub.12                                                                          R W W.sub.1                                                                           A  X.sub.1                                                                              Y.sub.1                                                                             Y.sub.2                                                                           m.p. °C.                            __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               CH.sub.3                                                                             O    --                                            1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               OCH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               OCF.sub.2 H                                                                          O    --                                            1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               CH.sub.3                                                                             CH.sub.2                                                                            --                                            1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                            --                                            1,3-dioxolan-2-yl                                                                       H  H O S  A-2                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                            --                                            1,3-dioxolan-2-yl                                                                       H  H O O  A-2                                                                               CH.sub.3                                                                             O    --                                            1,3-dioxolan-2-yl                                                                       H  H O O  A-2                                                                               OCH.sub.3                                                                            O    --                                            1,3-dioxolan-2-yl                                                                       H  H O O  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                            --                                            1,3-dithiolan-2-yl                                                                      H  H O S  A-2                                                                               CH.sub.3                                                                             O    --                                            1,3-dithiolan-2-yl                                                                      H  H O S  A-2                                                                               OCH.sub.3                                                                            CH   --                                            1,3-dithiolan-2-yl                                                                      H  H O O  A-2                                                                               CH.sub.3                                                                             O    --                                            1,3-dithiolan-2-yl                                                                      H  H O O  A-2                                                                               OCH.sub.3                                                                            CH   --                                            CH(OCH.sub.3).sub.2                                                                     H  H O S  A-2                                                                               CH.sub.3                                                                             O    --                                            CH(OCH.sub.3).sub.2                                                                     H  H O O  A-2                                                                               CH.sub.3                                                                             O    --                                            1,3-dioxolan-2-yl                                                                       H  H O S  A-3                                                                               CH.sub.3                                                                             --   --                                            1,3-dioxolan-2-yl                                                                       H  H O S  A-3                                                                               OCH.sub.3                                                                            --   --                                            1,3-dioxolan-2-yl                                                                       H  H O O  A-3                                                                               OCF.sub.2 H                                                                          --   --                                            1,3-dioxolan-2-yl                                                                       H  H O S  A-4                                                                               OCH.sub.3                                                                            --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                       H  H O S  A-4                                                                               CH.sub.3                                                                             --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                       H  H O S  A-4                                                                               OC.sub.2 H.sub.5                                                                     --   H                                             1,3-dioxolan-2-yl                                                                       H  H O O  A-4                                                                               CH.sub.3                                                                             --   CH.sub.3                                      1,3-dioxolan-2-yl                                                                       H  H O O  A-4                                                                               OCF.sub.2 H                                                                          --   CH.sub.3                                      1,3-dithiolan-2-yl                                                                      H  H O S  A-3                                                                               CH.sub.3                                                                             --   --                                            1,3-dithiolan-2-yl                                                                      H  H O S  A-4                                                                               CH.sub.3                                                                             --   CH.sub.3                                      CH(OCH.sub.3).sub.2                                                                     H  H O S  A-3                                                                               OCH.sub.3                                                                            --   --                                            CH(OCH.sub.3).sub.2                                                                     H  H O S  A-4                                                                               OCH.sub.3                                                                            --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               CH.sub. 3                                                                            O    --                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               OCH.sub.3                                                                            O    --                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               OCF.sub.2 H                                                                          O    --                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               CH.sub.3                                                                             CH.sub.2                                                                            --                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               OCH.sub.3                                                                            CH.sub.2                                                                            --                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-2                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                            --                                            C(OCH.sub.3).sub.3                                                                      H  H O O  A-3                                                                               CH.sub.3                                                                             --   --                                            C(OCH.sub.3).sub.3                                                                      H  H O O  A-3                                                                               OCH.sub.3                                                                            --   --                                            C(OCH.sub.3).sub.3                                                                      H  H O O  A-3                                                                               OCF.sub.2 H                                                                          --   --                                            C(OCH.sub.3).sub.3                                                                      H  H O O  A-4                                                                               OCH.sub.3                                                                            --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                      H  H O O  A-4                                                                               CH.sub.3                                                                             --   CH.sub.3                                      C(OCH.sub.3).sub.3                                                                      H  H O O  A-4                                                                               OC.sub.2 H.sub.5                                                                     --   H                                             C(OCH.sub.3).sub.3                                                                      H  H O O  A-4                                                                               OCF.sub.2 H                                                                          --   CH.sub.3                                      C(OCH.sub.3).sub. 3                                                                     H  H O O  A-2                                                                               CH.sub.3                                                                             O    --                                            C(OC.sub.2 H.sub.5).sub.3                                                               H  H O O  A-2                                                                               CH.sub.3                                                                             O    --                                            C(OC.sub.2 H.sub.5).sub.3                                                               H  H O S  A-2                                                                               CH.sub.3                                                                             O    --                                                                  X.sub.2                                                                              Y.sub.3                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                   C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             CH.sub.3                                           C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             C.sub.2 H.sub.5                                    C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                        C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               C.sub.2 H.sub.5                                                                      OCH.sub.3                                          C(OCH.sub.3).sub.3                                                                      H  H O S  A-5                                                                               CH.sub.2 CF.sub.3                                                                    OCH.sub. 3                                         C(OCH.sub.3).sub.3                                                                      H  H O O  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                          1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                           --                                            2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                    --                                            2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                                                           --                                            2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                                                    --                                            2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                                                         --                                            2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                                                         --                                            2-yl                                                                           CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                           --                                            CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             OC.sub.2 H.sub.5                                                                    --                                            CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             SCH.sub.3                                                                           --                                            CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             SC.sub.2 H.sub.5                                                                    --                                            CH(OCH.sub.3).sub.2                                                                     H  H O S  A-5                                                                               CH.sub.3                                                                             OCF.sub.2 H                                                                         --                                            CH(OCH.sub.3).sub. 2                                                                    H  H O S  A-5                                                                               CH.sub.3                                                                             SCF.sub.2 H                                                                         --                                            CH(OCH.sub.3).sub.2                                                                     H  H O O  A-5                                                                               CH.sub.3                                                                             OCH.sub.3                                                                           --                                                                  X.sub.3                                                  C(OCH.sub.3).sub.3                                                                      H  H O S  A-6                                                                               CH.sub.3                                                                             --   --                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-6                                                                               OCH.sub.3                                                                            --   --                                            1,3-dioxolan-                                                                           H  H O S  A-6                                                                               CH.sub.3                                                                             --   --                                            2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-6                                                                               OCH.sub.3                                                                            --   --                                            2-yl                                                                           CH(OCH.sub.3).sub.2                                                                     H  H O S  A-6                                                                               CH.sub.3                                                                             --   --                                            CH(OCH.sub.3).sub.2                                                                     H  H O S  A-6                                                                               OCH.sub.3                                                                            --   --                                            CH(OCH.sub.3).sub.2                                                                     H  H O O  A-6                                                                               CH.sub.3                                                                             --   --                                                                  X.sub.4                                                                              Y.sub.4                                                                             Z                                             CH(OCH.sub.3).sub.2                                                                     H  H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                            CH                                            CH(OCH.sub.3).sub.2                                                                     H  H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                            1,3-dioxolan-                                                                           H  H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                            CH                                            2-yl                                                                           1,3-dioxolan-                                                                           H  H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           CH                                            2-yl                                                                           C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                            CH                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                            N                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OCH.sub.3                                                                            CH.sub.3                                                                            CH                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OCH.sub.3                                                                            CH.sub.3                                                                            N                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                           N                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               Cl    CH.sub.3                                                                            CH                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OCH.sub.3                                                                            Cl   CH                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OC.sub.2 H.sub.5                                                                     CH.sub.3                                                                            CH                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               CH.sub.2 OCH.sub.3                                                                   CH.sub.3                                                                            N                                             C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               CH.sub.2 OCH.sub.3                                                                   OCH.sub.3                                                                           CH                                            C(OCH.sub.3).sub.3                                                                      H  H O S  A-7                                                                               OC.sub.2 H.sub.5                                                                     OC.sub.2 H.sub.5                                                                    N                                             C(OCH.sub.3).sub.3                                                                      H  H O O  A-7                                                                               CH.sub.3                                                                             CH.sub.3                                                                            CH                                            __________________________________________________________________________

                                      TABLE V                                      __________________________________________________________________________     General Structure V                                                            __________________________________________________________________________     R.sub.1  R.sub.11                                                                             R W A  X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                                                            m.p. °C.                             __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-2                                                                               CH.sub.3                                                                            O   --                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-2                                                                               OCF.sub.2 H                                                                         O   --                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-2                                                                               OCH.sub.3                                                                           O   --                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-2                                                                               CH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-2                                                                               OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                              1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                             H O A-2                                                                               CH.sub.3                                                                            O   --                                              1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                             H O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-3                                                                               CH.sub.3                                                                            --  --                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-3                                                                               OCH.sub.3                                                                           --  --                                              1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                        1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-4                                                                               OCH.sub.3                                                                           --  H                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                             H O A-4                                                                               OCF.sub.2 H                                                                         --  CH.sub.3                                        __________________________________________________________________________     R.sub.1  R.sub.11                                                                          R.sub.12                                                                          R W A.sub.1                                                                           X.sub.1                                                                             Y.sub.2                                                                            Y   m.p. °C.                             __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H  H O A-2                                                                               CH.sub.3                                                                            O   --                                              C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H  H O A-3                                                                               CH.sub.3                                                                            --  --                                              C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H  H O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                        __________________________________________________________________________                           X.sub.2                                                                             Y.sub.2                                             __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H  H O A-5                                                                               CH.sub.3                                                                            --  OCH.sub.3                                       1,3-dioxolan-                                                                           CH.sub.3                                                                          H  H O A-5                                                                               CH.sub.3                                                                            SCH.sub.3                                                                          --                                              2-yl                                                                           __________________________________________________________________________                           X.sub.3                                                  __________________________________________________________________________     C(CH.sub.3)(OCH.sub.3).sub.2                                                            CH.sub.3                                                                          H  H O A-6                                                                               CH.sub.3                                                                            --  --                                              C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H  H O A-6                                                                               OCH.sub.3                                                                           --  --                                              __________________________________________________________________________                           X.sub.4                                                                             Y.sub.4                                                                            Z                                               __________________________________________________________________________     1,3-dioxolan-                                                                           CH.sub.3                                                                          H  H O A-7                                                                               CH.sub.3                                                                            CH.sub.3                                                                           CH                                              2-yl                                                                           C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H  H O A-7                                                                               OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                              __________________________________________________________________________

                                      TABLE va                                     __________________________________________________________________________     General Structure Va                                                           R.sub.1  R.sub.11                                                                          R W A  X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                                                           m.p. °C.                                 __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCF.sub.2 H                                                                         O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            CH.sub.2                                                                           --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                                 1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-3                                                                               CH.sub.3                                                                            --  --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-3                                                                               OCH.sub.3                                                                           --  --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                           1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               OCH.sub.3                                                                           --  H                                                  1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               OCF.sub.2 H                                                                         --  CH.sub.3                                           C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-3                                                                               CH.sub.3                                                                            --  --                                                 C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                           __________________________________________________________________________                        X.sub.2                                                                             Y.sub.2                                                __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-5                                                                               CH.sub.3                                                                            OCH.sub.3                                              1,3-dioxolan-                                                                           CH.sub.3                                                                          H O A-5                                                                               CH.sub.3                                                                            SCH.sub.3                                              2-yl                                                                           __________________________________________________________________________                        X.sub.3                                                     __________________________________________________________________________     C(CH.sub.3)(OCH.sub.3).sub.2                                                            CH.sub.3                                                                          H O A-6                                                                               CH.sub.3                                                    C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-6                                                                               OCH.sub.3                                                   __________________________________________________________________________                        X.sub.4                                                                             Y.sub.4                                                                            Z                                                  __________________________________________________________________________     1,3-dioxolan-                                                                           CH.sub.3                                                                          H O A-7                                                                               CH.sub.3                                                                            CH.sub.3                                                                           CH                                                 2-yl                                                                           C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-7                                                                               OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                                 __________________________________________________________________________

                                      TABLE Vb                                     __________________________________________________________________________      General Structure Vb                                                          __________________________________________________________________________     R.sub.1  R.sub.11                                                                          R W A  X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                                                            m.p. °C.                                __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCF.sub.2 H                                                                         O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            CH.sub.3                                               1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                                 1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-3                                                                               CH.sub.3                                                                            --  --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-3                                                                               OCH.sub.3                                                                           --  --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                           1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               OCH.sub.3                                                                           --  H                                                  1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               OCF.sub.2 H                                                                         CH.sub.3                                               C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-3                                                                               CH.sub.3                                                                            --  --                                                 C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                           __________________________________________________________________________                        X.sub.2                                                                             Y.sub.3                                                __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-5                                                                               CH.sub.3                                                                            OCH.sub.3                                              1,3-dioxolan-                                                                           CH.sub.3                                                                          H O A-5                                                                               CH.sub.3                                                                            SCH.sub.3                                              2-yl                                                                           __________________________________________________________________________                        X.sub.3                                                     __________________________________________________________________________     C(CH.sub.3)(OCH.sub.3).sub.2                                                            CH.sub.3                                                                          H O A-6                                                                               CH.sub.3                                                                            --  --                                                 C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-6                                                                               OCH.sub.3                                                                           --  --                                                 __________________________________________________________________________                        X.sub.4                                                                             Y.sub.4                                                                            Z                                                  __________________________________________________________________________     1,3-dioxolan-                                                                           CH.sub.3                                                                          H O A-7                                                                               CH.sub.3                                                                            CH.sub.3                                                                           CH                                                 2-yl                                                                           C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-7                                                                               OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                                 __________________________________________________________________________

                                      TABLE Vc                                     __________________________________________________________________________      General Structure Vc                                                          __________________________________________________________________________     R.sub.1  R.sub.11                                                                          R W A  X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                                                            m.p. °C.                                __________________________________________________________________________     1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCF.sub.2 H                                                                         O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           O   --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            CH.sub.2                                                                           --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-2                                                                               OC.sub.2 H.sub.5                                                                    CH.sub.2                                                                           --                                                 1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 1,3-dithiolan-2-yl                                                                      CH.sub.3                                                                          H O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-3                                                                               CH.sub.3                                                                            --  --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-3                                                                               OCH.sub.3                                                                           --  --                                                 1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                           1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               OCH.sub.3                                                                           --  H                                                  1,3-dioxolan-2-yl                                                                       CH.sub.3                                                                          H O A-4                                                                               OCF.sub.2 H                                                                         --  CH.sub.3                                           C(OCH.sub.3 ).sub.3                                                                     CH.sub.3                                                                          H O A-2                                                                               CH.sub.3                                                                            O   --                                                 C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-3                                                                               CH.sub.3                                                                            --  --                                                 C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                           __________________________________________________________________________                        X.sub.2                                                                             Y.sub.3                                                __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-5                                                                               CH.sub.3                                                                            OCH.sub.3                                              1,3-dioxolan-                                                                           CH.sub.3                                                                          H O A-5                                                                               CH.sub.3                                                                            SCH.sub.3                                              2-yl                                                                           __________________________________________________________________________                        X.sub.3                                                     __________________________________________________________________________     C(CH.sub.3)(OCH.sub.3).sub.2                                                            CH.sub.3                                                                          H O A-6                                                                               CH.sub.3                                                                            --  --                                                 C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-6                                                                               OCH.sub.3                                                                           --  --                                                 __________________________________________________________________________                        X.sub.4                                                                             Y.sub.4                                                                            Z                                                  __________________________________________________________________________     1,3-dioxolan-                                                                           CH.sub.3                                                                          H O A-7                                                                               CH.sub.3                                                                            CH.sub.3                                                                           CH                                                 2-yl                                                                           C(OCH.sub.3).sub.3                                                                      CH.sub.3                                                                          H O A-7                                                                               OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                                 __________________________________________________________________________

                                      TABLE VI                                     __________________________________________________________________________      General Structure VI                                                          __________________________________________________________________________     R.sub.1   R   W  A   X.sub.1                                                                              Y.sub.1                                                                            Y.sub.2                                                                             m.p. ° C.                           __________________________________________________________________________     1,3-dioxolan-2-yl                                                                        H   O  A-2 CH.sub.3                                                                             O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCF.sub.2 H                                                                          O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCH.sub.3                                                                            O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 CH.sub.3                                                                             CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                           --                                              1,3-dithiolan-2-yl                                                                       H   O  A-2 CH.sub.3                                                                             O   --                                              1,3-dithiolan-2-yl                                                                       H   O  A-2 OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   O  A-3 CH.sub.3                                                                             --  --                                              1,3-dioxolan-2-yl                                                                        H   O  A-3 OCH.sub.3                                                                            --  --                                              1,3-dioxolan-2-yl                                                                        H   O  A-4 CH.sub.3                                                                             --  CH.sub.3                                        1,3-dioxolan-2-yl                                                                        H   O  A-4 OCH.sub.3                                                                            --  H                                               1,3-dioxolan-2-yl                                                                        H   O  A-4 OCF.sub.2 H                                                                          --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-2 CH    O.sub.3                                                                            --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-3 CH.sub.3                                                                             --  --                                              C(OCH.sub.3).sub.3                                                                       CH.sub. 3                                                                          O  A-4 CH.sub.3                                                                             --  CH.sub.3                                        __________________________________________________________________________                          X.sub.2                                                                              Y.sub.3                                             __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-5 CH.sub.3                                                                             OCH.sub.3                                           1,3-dioxolan-                                                                            CH.sub.3                                                                           O  A-5 CH.sub.3                                                                             SCH.sub.3                                           2-yl                                                                           __________________________________________________________________________                          X.sub.3                                                   __________________________________________________________________________     C(CH.sub.3)(OCH.sub.3).sub.2                                                             CH.sub.3                                                                           O  A-6 CH.sub.3                                                                             --  --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-6 OCH   --.sub.3                                                                           --                                              __________________________________________________________________________                          X.sub.4                                                                              Y.sub.4                                                                            Z                                               __________________________________________________________________________     1,3-dioxolan-                                                                            CH.sub.3                                                                           O  A-7 CH    CH.sub.3                                                                           CH.sub.3                                        2-yl                                                                           C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-7 OCH   OCH.sub.3                                                                          CH.sub.3                                        __________________________________________________________________________

                                      TABLE VIa                                    __________________________________________________________________________      General Structure VIa                                                         __________________________________________________________________________     R.sub.1   R   W  A   X.sub.1                                                                              Y.sub.1                                                                            Y.sub.2                                                                             m.p. ° C.                           __________________________________________________________________________     1,3-dioxolan-2-yl                                                                        H   O  A-2 CH.sub.2                                                                             O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCF.sub.2 H                                                                          O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCH.sub.3                                                                            O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 CH.sub.3                                                                             CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   0  2   OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                           --                                              1,3-dithiolan-2-yl                                                                       H   O  A-2 CH.sub.3                                                                             O   --                                              1,3-dithiolan-2-yl                                                                       H   O  A-2 OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   O  A-3 CH.sub.3                                                                             --  --                                              1,3-dioxolan-2-yl                                                                        H   O  A-3 OCH.sub.3                                                                            --  --                                              1,3-dioxolan-2-yl                                                                        H   O  A-4 CH.sub.3                                                                             --  CH.sub.3                                        1,3-dioxolan-2-yl                                                                        H   O  A-4 OCH.sub.3                                                                            --  H                                               1,3-dioxolan-2-yl                                                                        H   O  A-4 OCF.sub.2 H                                                                          --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-2 CH.sub.3                                                                             O   --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-3 CH.sub.3                                                                             --  --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-4 CH.sub.3                                                                             --  CH.sub.3                                        __________________________________________________________________________                          X.sub.2                                                                              Y.sub.3                                             __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-5 CH.sub.3                                                                             OCH.sub.3                                           1,3-dioxolan-                                                                            CH.sub.3                                                                           O  A-5 CH.sub.3                                                                             SCH.sub.3                                           2-yl                                                                           __________________________________________________________________________                          X.sub.3                                                   __________________________________________________________________________     C(CH.sub.3)(OCH.sub.3).sub.2                                                             CH.sub.3                                                                           O  A-6 CH.sub.3                                                                             --  --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-6 OCH.sub.3                                                                            --  --                                              __________________________________________________________________________                          X.sub.4                                                                              Y.sub.4                                                                            Z                                               __________________________________________________________________________     1,3-dioxolan-                                                                            CH.sub.3                                                                           O  A-7 CH.sub.3                                                                             CH.sub.3                                                                           CH                                              2-yl                                                                           C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-7 OCH.sub.3                                                                            OCH.sub.3                                                                          CH                                              __________________________________________________________________________

                                      TABLE VIb                                    __________________________________________________________________________      General Structure VIb                                                         __________________________________________________________________________     R.sub.1   R   W  A   X.sub.1                                                                              Y.sub.1                                                                            Y.sub.2                                                                             m.p. ° C.                           __________________________________________________________________________     1,3-dioxolan-2-yl                                                                        H   O  A-2 CH.sub.3                                                                             O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCF.sub.2 H                                                                          O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCH.sub.3                                                                            O   --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 CH.sub.3                                                                             CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   O  A-2 OC.sub.2 H.sub.5                                                                     CH.sub.2                                                                           --                                              1,3-dithiolan-2-yl                                                                       H   O  A-2 CH.sub.3                                                                             O   --                                              1,3-dithiolan-2-yl                                                                       H   O  A-2 OCH.sub.3                                                                            CH.sub.2                                                                           --                                              1,3-dioxolan-2-yl                                                                        H   O  A-3 CH.sub.3                                                                             --  --                                              1,3-dioxolan-2-yl                                                                        H   O  A-3 OCH.sub.3                                                                            --  --                                              1,3-dioxolan-2-yl                                                                        H   O  A-4 CH.sub.3                                                                             --  CH.sub.3                                        1,3-dioxolan-2-yl                                                                        H   O  A-4 OCH.sub.3                                                                            --  H                                               1,3-dioxolan-2-yl                                                                        H   O  A-4 OCF.sub.2 H                                                                          --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-2 CH.sub.3                                                                             O   --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-2 CH.sub.3                                                                             O   --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-3 CH.sub.3                                                                             --  --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-4 CH.sub.3                                                                             --  CH.sub.3                                        __________________________________________________________________________                          X.sub.2                                                                              Y.sub.3                                             __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-5 CH.sub.3                                                                             OCH.sub.3                                           1,3-dioxolan-                                                                            CH.sub.3                                                                           O  A-5 CH.sub.3                                                                             SCH.sub.3                                           2-yl                                                                           __________________________________________________________________________                          X.sub.3                                                   __________________________________________________________________________     C(CH.sub.3)(OCH.sub.3).sub.2                                                             CH.sub.3                                                                           O  A-6 CH.sub.3                                                                             --  --                                              C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-6 OCH.sub.3                                                                            --  --                                              __________________________________________________________________________                          X.sub.4                                                                              Y.sub.4                                                                            Z                                               __________________________________________________________________________     1,3-dioxolan-                                                                            CH.sub.3                                                                           O  A-7 CH.sub.3                                                                             CH.sub.3                                                                           CH                                              2-yl                                                                           C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                           O  A-7 OCH.sub.3                                                                            OCH.sub.3                                                                          CH                                              __________________________________________________________________________

                                      TABLE VII                                    __________________________________________________________________________     General Structure VII                                                          R.sub.1   R  R.sub.14                                                                            E  W X      Y        Z  m.p. °C.                      __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              CH.sub.3 CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O Cl     OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O Br     OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              H        CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             H        CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             CH.sub.2 OC.sub.2 H.sub.5                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCF.sub.2 H                                                                           OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             CH(OCH.sub.3).sub.2                                                                     CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              OC.sub.2 H.sub.5                                                                        CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              CH.sub.2 OCH.sub.3                                                                      CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                      CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             C.sub.2 H.sub.5                                                                         CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OC.sub.2 H.sub.5                                                                      OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCF.sub.2 H                                                                           OCF.sub.2 H                                                                             CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.2 F                                                                            OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.2 Cl                                                                           OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CF.sub.3                                                                              OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O Cl     OC.sub.2 H.sub.5                                                                        CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.2 CH.sub.2 F                                                                  OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              OCH.sub.3                                                                               N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              CH.sub.3 N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             cyclo-   N                                                                     propyl                                           C(OCH.sub.3).sub.3                                                                       H  H    -- O OC.sub.2 H.sub.5                                                                      NHCH.sub.3                                                                              N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.2 CF.sub.3                                                                    OCH.sub.3                                                                               N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.2 CH.sub.2 F                                                                  CH.sub.3 N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.2 CH.sub.2 F                                                                  OCH.sub.3                                                                               N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- S OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  3-F  -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  5-Cl -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  5-CH.sub.3                                                                          -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  5-C.sub.2 H.sub.5                                                                   -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  6-OCH.sub.3                                                                         -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  6-OC.sub.2 H.sub.5                                                                  -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  6-SCH.sub.3                                                                         -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  6-SC.sub.2 H.sub.5                                                                  -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  5-Br -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    CH.sub.2                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OC.sub.2 H.sub.5).sub.3                                                                H  H    CH.sub.2                                                                          O CH.sub.3                                                                              CH.sub.3 CH                                      C(OC.sub.2 H.sub.5).sub.3                                                                H  H    CH.sub.2                                                                          O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                      C(OC.sub.2 H.sub.5).sub.3                                                                H  H    CH.sub.2                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OC.sub.2 H.sub.5).sub.3                                                                H  H    CH.sub.2                                                                          O Cl     OCH.sub.3                                                                               CH                                      C(OC.sub.2 H.sub.5).sub.3                                                                H  H    CH.sub.2                                                                          O CH.sub.3                                                                              OCH.sub.3                                                                               N                                       C(OC.sub.2 H.sub.5).sub.3                                                                H  H    CH.sub.2                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                       C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H    CH.sub.2                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H    CH.sub.2                                                                          O CH.sub.3                                                                              OCH.sub.3                                                                               CH                                      C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H    CH.sub.2                                                                          O CH.sub.3                                                                              CH.sub.3 CH                                      C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H    CH.sub.2                                                                          O Cl     OCH.sub.3                                                                               CH                                      C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H    CH.sub.2                                                                          O CH.sub.3                                                                              OCH.sub.3                                                                               N                                       C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H  H    CH.sub.2                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               N                                       C(OCH.sub.3).sub.3                                                                       CH.sub.3                                                                          H    CH.sub.2                                                                          O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OCH.sub.3).sub.3                                                                       H  H    CH.sub.2                                                                          O OCH.sub.2 CHF.sub.2                                                                   CH.sub.3 N                                       C(OCH.sub.3).sub.3                                                                       H  H    CH.sub.2                                                                          O CH.sub.3                                                                              i-C.sub.3 H.sub.7                                                                       CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             N(OCH.sub.3)CH.sub.3                                                                    N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              N(CH.sub.2).sub.3                                                                       N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             CF.sub.3 CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              SCH.sub.3                                                                               N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              OCH.sub.2 CH=CH.sub.2                                                                   N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              OCH.sub.2 CH.tbd.CH                                                                     N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O CH.sub.3                                                                              CH.sub.2 SCH.sub.3                                                                      N                                       C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             SCF.sub.2 H                                                                             CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             1,3-dioxolan-2-yl                                                                       CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             4-methyl-1,3-                                                                           N                                                                     dioxolan-2-yl                                    C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             4-ethyl-1,3-                                                                            CH                                                                    dioxolan-2-yl                                    C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             1,3-dithiolan-2-yl                                                                      CH                                      C(OCH.sub.3).sub.3                                                                       H  H    -- O OCH.sub.3                                                                             1,3-oxathiolan-2-yl                                                                     N                                       C(OCH.sub.3)(OC.sub.2 H.sub.5).sub.2                                                     H  H    -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      C(OC.sub.2 H.sub.5)(OCH.sub.3).sub.2                                                     H  H    -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      2-methoxy-1,3-                                                                           H  H    -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      dioxolan-2-yl                                                                  2-ethoxy-1,3-                                                                            H  H    -- O OCH.sub.3                                                                             OCH.sub.3                                                                               CH                                      dioxolan-2-yl                                                                  __________________________________________________________________________

                                      TABLE VIIa                                   __________________________________________________________________________     General Structure VIIa                                                         R.sub.1   R R.sub.14                                                                          E W A  X.sub.1                                                                             Y.sub.1                                                                            Y.sub.2                                                                           m.p. °C.                              __________________________________________________________________________     C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-2                                                                               CH.sub.3                                                                            O   --                                              C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-2                                                                               OCH.sub.3                                                                           O   --                                              C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-2                                                                               OCH.sub.3                                                                           CH.sub.2                                                                           --                                              C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-2                                                                               OCF.sub.2 H                                                                         O   --                                              C(OC.sub.2 H.sub.5).sub.3                                                                H H  --                                                                               O A-2                                                                               CH.sub.3                                                                            O   --                                              C(OC.sub.2 H.sub.5).sub.3                                                                H H  --                                                                               O A-2                                                                               OCH.sub.3                                                                           O   --                                              C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H H  --                                                                               O A-2                                                                               CH.sub.3                                                                            O   --                                              C(OCH.sub.2 CH.sub.2 CH.sub.3).sub.3                                                     H H  --                                                                               O A-2                                                                               OCH.sub.3                                                                           O   --                                              C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-3                                                                               CH.sub.3                                                                            --  --                                              C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-3                                                                               OCH.sub.3                                                                           --  --                                              C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-4                                                                               CH.sub.3                                                                            --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-4                                                                               OCH.sub.3                                                                           --  CH.sub.3                                        C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-4                                                                               OCH.sub.3                                                                           --  H                                                                     X.sub.2                                                                             Y.sub.3                                             C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-5                                                                               CH.sub.3                                                                            OCH.sub.3                                           C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-5                                                                               CH.sub.3                                                                            SCH.sub.3                                           C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-5                                                                               CH.sub.3                                                                            CH.sub.3                                                                  X.sub.3                                                  C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-6                                                                               CH.sub.3                                                 C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-6                                                                               OCH.sub.3                                                                      X.sub.4                                                                             Y.sub.4                                                                            Z                                               C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-7                                                                               CH.sub.3                                                                            CH.sub.3                                                                           CH                                              C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-7                                                                               OCH.sub.3                                                                           OCH.sub.3                                                                          CH                                              C(OCH.sub.3).sub.3                                                                       H H  --                                                                               O A-7                                                                               OCH.sub. 3                                                                          OCH.sub.3                                                                          N                                               __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 5% to 99% solid or liquid diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:

    ______________________________________                                                     Active  Weight Percent*                                                        Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             20-90     0-74      1-10                                         Oil Suspensions,                                                                             5-50      40-95     0-15                                         Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Aqueous Suspension                                                                           10-50     40-84     1-20                                         Dusts         1-25      70-99     0-5                                          Granules and Pellets                                                                         1-95      5-99      0-15                                         High Strength 90-99     0-10      0-2                                          Compositions                                                                   ______________________________________                                          *Active ingredient plus at least one of a Surfactant or a Diluent equals       100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, N.J. The more absorptive diluents are preferred for wettable powder and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., Interscience, New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, N.J., as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc. Preferably, ingredients should be approved by the U.S. Environmental Protection Agency for the use intended.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually, grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preferred granular carriers or by agglomeration techniques.

In the following examples, all parts are by weight unless otherwise indicated.

EXAMPLE 5 Wettable Powder

    ______________________________________                                         3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                 sulfonamide               80%                                                  sodium alkylnaphthalenesulfonate                                                                         2%                                                   sodium ligninsulfonate    2%                                                   synthetic amorphous silica                                                                               3%                                                   kaolinite                 13%                                                  ______________________________________                                    

The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged.

EXAMPLE 6 Wettable Powder

    ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                             (1,3-dioxolan-2-yl)-2-thiophenesulfonamide                                                                50%                                                 sodium alkylnaphthalenesulfonate                                                                          2%                                                  low viscosity methyl cellulose                                                                            2%                                                  diatomaceous earth         36%                                                 ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.

EXAMPLE 7 High Strength Concentrate

    ______________________________________                                         3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                 sulfonamide               99%                                                  silica aerogel            0.5%                                                 synthetic amorphous silica                                                                               0.5%                                                 ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary.

EXAMPLE 8 Wettable Powder

    ______________________________________                                         3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                 sulfonamide               20%                                                  sodium alkylnaphthalenesulfonate                                                                         4%                                                   sodium ligninsulfonate    4%                                                   low viscosity methyl cellulose                                                                           3%                                                   attapulgite               69%                                                  ______________________________________                                    

The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve (0.3 mm opening) and packaged.

EXAMPLE 9 Oil Suspension

    ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                             (1,3-dioxolan-2-yl)-2-thiophenesulfonamide                                                                25%                                                 polyoxyethylene sorbitol hexaoleate                                                                       5%                                                  highly aliphatic hydrocarbon oil                                                                          70%                                                 ______________________________________                                    

The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.

EXAMPLE 10 Oil Suspension

    ______________________________________                                         3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                 sulfonamide               35%                                                  blend of polyalcohol carboxylic                                                                          6%                                                   esters and oil soluble petroleum                                               sulfonates                                                                     xylene                    59%                                                  ______________________________________                                    

The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE 11 Aqueous Suspension

    ______________________________________                                         3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                 sulfonamide               40%                                                  polyacrylic acid thickener                                                                               0.3%                                                 dodecylphenol polyethylene                                                     glycol ether              0.5%                                                 disodium phosphate        1%                                                   monosodium phosphate      0.5%                                                 polyvinyl alcohol         1.0%                                                 water                     56.7%                                                ______________________________________                                    

The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size.

EXAMPLE 12 Solution

    ______________________________________                                         3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                 sulfonamide               30%                                                  dimethylformamide         70%                                                  ______________________________________                                    

The ingredients are combined and stirred to produce a solution, which can be used for low volume applications.

EXAMPLE 13 Dust

    ______________________________________                                         wettable powder of Example 6                                                                        10%                                                       Pyrophyllite (powder)                                                                               90%                                                       ______________________________________                                    

The wettable powder and the pyrophyllite diluent are thoroughly blended and then packaged. The product is suitable for use a a dust.

EXAMPLE 14 Low Strength Granule

    ______________________________________                                         3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                 sulfonamide               0.1%                                                 attapulgite granules      99.9%                                                (U.S.S. 20-40 mesh)                                                            ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.

EXAMPLE 15 Granule

    ______________________________________                                         Wettable Powder of Example 6                                                                        5%                                                        attapulgite granules 95%                                                       (U.S.S. 20-40 mesh: 0.84-0.42 mm)                                              ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.

EXAMPLE 16 Granule

    ______________________________________                                         N--[](4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                            (1,3-dioxolan-2-yl)-2-thiophenesulfonamide                                                                 80%                                                wetting agent               1%                                                 crude ligninsulfonate salt (containing                                                                     10%                                                5-20 of the natural sugars)                                                    attapulgite clay            9%                                                 ______________________________________                                    

The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14-100 mesh (1410-149 microns), and packaged for use.

EXAMPLE 17 Extruded Pellet

    ______________________________________                                         3-(1,3-dioxolan-2-yl)-N--[(4-methoxy-6-methyl-                                 1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophene-                                 sulfonamide               25%                                                  anhydrous sodium sulfate  10%                                                  crude calcium ligninsulfonate                                                                            5%                                                   sodium alkylnaphthalenesulfonate                                                                         1%                                                   calcium/magnesium bentonite                                                                              59%                                                  ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.

Utility

Test results indicate that the compounds of the present invention are active herbicides. They have utility for broad-spectrum pre- and/or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, ammunition depots, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Alternatively, the subject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.01 to 5.0 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any other commercial herbicide; examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate and bipyridylium types.

The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow. ##STR29##

Test A

Seeds of crabgrass (Digitaria sp.), barnyardgrass (Echinochloa crusgalli), wild oats (Avena fatua), sicklepod (Cassia obtusifolia), morningglory (Ipomoea spp.), cocklebur (Xanthium pensylvanicum), sorghum, corn, soybean, sugar beet, cotton, rice, wheat and purple nutsedge (Cyperus rotundus) tubers were planted and treated pre-emergence with the test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were treated with a soil/foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table A, are based on a numerical scale extending from 0=no injury, to 10=complete kill. The accompanying descriptive symbols have the following meanings:

C=chlorosis or necrosis;

B=burn

D=defoliation

E=emergence inhibition;

G=growth retardation; and

H=formative effects.

U=unusual pigmentation

X=axillary stimulation

S=albinism

6Y=abscised buds or flowers.

                  TABLE A                                                          ______________________________________                                                        Compound 1   Compound 2                                         Rate kg/ha     0.05         0.05                                               ______________________________________                                         POST-EMERGENCE                                                                 Morningglory   9C           10C                                                Cocklebur      9C           10C                                                Sicklepod      2C,5G        7G                                                 Nutsedge       4G           10C                                                Crabgrass      3C,8G        5C,9G                                              Barnyardgrass  5C,9H        9C                                                 Wild Oats      8G           5C,9G                                              Wheat          5G           6C,9G                                              Corn           2C,9G        3C,9G                                              Soybean        9C           9C                                                 Rice           9C           9C                                                 Sorghum        9G           5C,9G                                              Sugar beet     10C          9C                                                 Cotton         9C           9C                                                 PRE-EMERGENCE                                                                  Morningglory   9G           4C,9G                                              Cocklebur      8H           9H                                                 Sicklepod      9G           9G                                                 Nutsedge       0            10E                                                Crabgrass      2C,5G        7G                                                 Barnyardgrass  3C,7H        9H                                                 Wild Oats      6C,9G        5C,9G                                              Wheat          5G           4C,9G                                              Corn           5C,9H        9G                                                 Soybean        9H           9H                                                 Rice           10E          10E                                                Sorghum        5C,9H        6C,9H                                              Sugar beet     5C,9G        9C                                                 Cotton         2C,9G        9G                                                 ______________________________________                                                        Compound 3   Compound 4                                         Rate kg/ha     0.05         0.05                                               ______________________________________                                         POST-EMERGENCE                                                                 Morningglory   10C          10C                                                Cocklebur      4C,9H        9C                                                 Velvetleaf     9C           9C                                                 Nutsedge       9C           8C                                                 Crabgrass      7H           7G                                                 Barnyardgrass  9C           9C                                                 Cheatgrass     10C          6C,9G                                              Wild Oats      2C,5G        2G                                                 Wheat          2G           2G                                                 Corn           7U,9C        10C                                                Soybean        9C           9C                                                 Rice           9C           9C                                                 Sorghum        5C,9H        2U,8H                                              Sugar beet     9C           9C                                                 Cotton         9C           9C                                                 PRE-EMERGENCE                                                                  Morningglory   9C           9G                                                 Cocklebur      7H           8H                                                 Velvetleaf     10C          9C                                                 Nutsedge       10E          10E                                                Crabgrass      2C,7G        4C,9G                                              Barnyardgrass  9H           9H                                                 Cheatgrass     4C,9H        3C,9H                                              Wild Oats      8G           8G                                                 Wheat          2C,8H        8G                                                 Corn           9H           4C,9H                                              Soybean        8H           9H                                                 Rice           10E          10E                                                Sorghum        9H           3C,9H                                              Sugar beet     5C,9G        5C,9G                                              Cotton         9G           9G                                                 ______________________________________                                                        Compound 5   Compound 6                                         Rate kg/ha     0.05         0.05                                               ______________________________________                                         POST-EMERGENCE                                                                 Morningglory   10C          10C                                                Cocklebur      9H           9C                                                 Velvetleaf     2C,7G        9C                                                 Nutsedge       4G           9C                                                 Crabgrass      2G           2C,6G                                              Barnyardgrass  9C           3C,9H                                              Cheatgrass     0            3C,8G                                              Wild Oats      0            0                                                  Wheat          0            0                                                  Corn           7U,9C        2C,8H                                              Soybean        5C,9G        5C,9G                                              Rice           4C,8G        4C,9G                                              Sorghum        3C,9H        4C,9H                                              Sugar beet     9C           9C                                                 Cotton         5C,9G        9C                                                 PRE-EMERGENCE                                                                  Morningglory   9G           9H                                                 Cocklebur      3H           8H                                                 Velvetleaf     5G           9G                                                 Nutsedge       3G           2C,9G                                              Crabgrass      2G           0                                                  Barnyardgrass  3C,7G        4C,9H                                              Cheatgrass     6G           3C,8G                                              Wild Oats      3G           5G                                                 Wheat          2G           4G                                                 Corn           2C,9G        8G                                                 Soybean        2C,5G        9H                                                 Rice           3C,8H        4C,9H                                              Sorghum        3C,9H        4C,8H                                              Sugar beet     5C,9G        9C                                                 Cotton         2C,8G        9G                                                 ______________________________________                                                       Compound  Compound   Compound                                                  7         8          9                                           Rate kg/ha    0.05      0.05       0.05                                        ______________________________________                                         POST-EMERGENCE                                                                 Morningglory  6C,9G     9C         10C                                         Cocklebur     9C        10C        9C                                          Velvetleaf    6C,9G     10C        9C                                          Nutsedge      6G        3G         4C,8G                                       Crabgrass     5G        4G         0                                           Barnyardgrass 4C,9H     4C,9H      8H                                          Cheatgrass    0         2C,3H      0                                           Wild Oats     0         0          0                                           Wheat         0         0          0                                           Corn          2C,9G     5C,9G      1H                                          Soybean       5C,9G     5C,9G      3H,9G,7X                                    Rice          7G        5G         6G                                          Sorghum       3C,9H     5C,9H      9H                                          Sugar beet    3C,9G     9C         9C                                          Cotton        9C        9C         9C                                          PRE-EMERGENCE                                                                  Morningglory  8H        8G         8G                                          Cocklebur     9H        5G         7G                                          Velvetleaf    4C,8G     3C,8G      4G                                          Nutsedge      0         3G         3G                                          Crabgrass     0         0          0                                           Barnyardgrass 0         3C,7H      4G                                          Cheatgrass    3G        0          0                                           Wild Oats     0         0          0                                           Wheat         0         0          0                                           Corn          2C,8H     3C,9H      4G                                          Soybean       3C,8H     3C,8H      5H                                          Rice          3C,5H     3C,7G      0                                           Sorghum       3C,9H     5C,9H      2C,7G                                       Sugar beet    5C,9G     5C,9G      7G                                          Cotton        3C,8G     8G         8G                                          ______________________________________                                     

What is claimed is:
 1. A compound of the formula ##STR30## wherein Q is ##STR31## R is H or CH₃ ; R₁ is ##STR32## E is CH₂ or a single bond; R₂ is H, C₁ -C₂ alkyl or Cl;R₃ is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy; R₄ and R₅ are independently C₁ -C₂ alkyl; R₆ and R₇ are independently H or C₁ -C₂ alkyl; W is O or S; W₁ is O or S; Q₁ and Q₂ are independently O, S or NCH₃ ; ##STR33## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃)alkylamino; Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylsulfinylalkyl, C₁ -C₄ haloalkyl, C₂ -C₅ alkylsulfonylalkyl, C₃ -C₅ cycloalkyl, C₂ -C₄ alkynyl, C₂ -C₅ alkylthioalkyl, C(O)R₈, ##STR34## or N(OCH₃)CH₃ ; m is 2 or 3; L₁ and L₂ are independently O or S; R₈ is H or CH₃ ; R₉ and R₁₀ are independently C₁ -C₂ alkyl; R₁₁ is C₁ -C₃ alkyl; R₁₂ is H, F, Cl, NO₂, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, C₁ -C₂ alkylthio, C₁ -C₂ alkylsulfinyl, C₁ -C₂ alkylsulfonyl, di(C₁ -C₂)alkylsulfamoyl or CO₂ (C₁ -C₂ alkyl); R₁₃ is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F or NO₂ ; R₁₄ is H, C₁ -C₃ alkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkyl, C₁ -C₃ haloalkoxy, Cl, Br, F, NO₂, di(C₁ -C₃) alkylsulfamoyl, C₁ -C₃ alkylthio, C₁ -C₃ alkylsulfinyl, C₁ -C₃ alkylsulfonyl, amino, C₁ -C₃ alkylamino, di(C₁ -C₃)alkylamino, CH₂ OCH₃, CH₂ SCH₃ or CH₂ CN. Z is N; X₃ is CH₃ or OCH₃ ;and their agriculturally suitable salts; provided that (a) when R₃ is C₁ -C₃ alkoxy, then Q₁ and Q₂ are oxygen; (b) when R₃ is H or C₁ -C₃ alkyl, then Q is Q-1 through Q-9; (c) X or Y are other than OCF₂ H; (d) when the total number of carbon atoms of X and Y is greater than four, then the combined number of carbons of the substituents on Q is less than or equal to ten; (e) when W is S, then A is A-1, R is H, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR35## (f) when E is CH₂, then R₁₄ is H, CH₃, OCH₃, Cl or NO₂ and is not in the 4-position.
 2. A compound of claim 1 where R₃ is H or C₁ -C₃ alkyl.
 3. A compound of claim 1 where R₃ is C₁ -C₃ alkoxy.
 4. A compound of claim 2 where W is O; R is H; X is CH₃, OCH₃, OC₂ H₅, CH₂ F, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ; and Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, (OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, CH₂ OC₂ H₅, ##STR36## SCF₂ H, cyclopropyl, C.tbd.CH or C.tbd.CCH₃.
 5. A compound of claim 4 where Q₁ and Q₂ are identical and are O or S, R₁₂ is H, C₁ -C₂ alkyl or Cl and R₁₃ is H.
 6. A compound of claim 5 where A is A-1; Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, NHCH₃, CH₂ OC₂ H₅, OCH₂ CH₂ OCH₃, cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ; and X is CH₃, OCH₃, OC₂ H₅, or OCH₂ CF₃.
 7. A compound of claim 6 where Q₁ and Q₂ are O.
 8. A compound of claim 6 where Q₁ and Q₂ are S.
 9. A compound of claim 6 where Q is Q-1.
 10. A compound of claim 6 where Q is Q-2.
 11. A compound of claim 6 where Q is Q-3.
 12. A compound of claim 6 where Q is Q-4.
 13. A compound of claim 6 where Q is Q-5.
 14. A compound of claim 6 where Q is Q-6.
 15. A compound of claim 6 where Q is Q-7.
 16. A compound of claim 6 where Q is Q-8.
 17. A compound of claim 6 where Q is Q-9.
 18. A compound of claim 3 where W is O; R is H; X is CH₃, OCH₃, OC₂ H₅, CH₂ F, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃ or CF₃ ; and Y is H, C₁ -C₃ alkyl, OCH₃, OC₂ H₅, CH₂ OCH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, CH₂ OC₂ H₅, ##STR37## SCF₂ H, cyclopropyl, C.tbd.CH or C.tbd.CCH₃.
 19. A compound of claim 18 where E is a single bond; R₁₂ is H, C₁ -C₂ alkyl or Cl; R₁₃ is H; and R₁₄ is H, F, Cl, Br, C₁ -C₂ alkyl, C₁ -C₂ alkoxy or C₁ -C₂ alkylthio and is not para to the sulfonylurea bridge.
 20. A compound of claim 19 where A is A-1; Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, NHCH₃, CH₂ OC₂ H₅, OCH₂ CH₂ OCH₃, cyclopropyl, C.tbd.CH or CH(OCH₃)₂ ; and X is CH₃, OCH₃, OC₂ H₅, or OCH₂ CF₃.
 21. A compound of claim 20 where Q is Q-1.
 22. A compound of claim 20 where Q is Q-2.
 23. A compound of claim 20 where Q is Q-3.
 24. A compound of claim 20 where Q is Q-4.
 25. A compound of claim 20 where Q is Q-5.
 26. A compound of claim 20 where Q is Q-6.
 27. A compound of claim 20 where Q is Q-7.
 28. A compound of claim 20 where Q is Q-8.
 29. A compound of claim 20 where Q is Q-9.
 30. A compound of claim 20 where Q is Q-10.
 31. A compound of claim 1 which is 3-(1,3-dioxolan-2-yl)-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-thiophenesulfonamide.
 32. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 1 and at least one of the following: surfactant, solid or liquid inert diluent.
 33. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 2 and at least one of the following: surfactant, solid or liquid inert diluent.
 34. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 3 and at least one of the following: surfactant, solid or liquid inert diluent.
 35. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 4 and at least one of the following: surfactant, solid or liquid inert diluent.
 36. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 5 and at least one of the following: surfactant, solid or liquid inert diluent.
 37. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 6 and at least one of the following: surfactant, solid or liquid inert diluent.
 38. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 18 and at least one of the following: surfactant, solid or liquid inert diluent.
 39. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 19 and at least one of the following: surfactant, solid or liquid inert diluent.
 40. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of a compound of claim 20 and at least one of the following: surfactant, solid or liquid inert diluent.
 41. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 1. 42. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 2. 43. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 3. 44. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 4. 45. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 5. 46. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 6. 47. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 18. 48. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 19. 49. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of a compound of claim
 20. 